Browsing Chemistry (Scholarly Publications) by Author "El-Sagheer, Afaf"
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Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A
McGouran, Joanna; Dürr, Eva-Maria; Doherty, William; Lee, Sook Y.; El-Sagheer, Afaf; Shivalingam, Arun; McHugh, Peter J.; Brown, Tom (2018)Phosphate groups are often crucial to biological activity and interactions of oligonucleotides, but confer poor membrane permeability. In addition, the group's lability to enzymatic hydrolysis is an obstacle to its use in ...