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  • Squaramide-Based 5'-Phosphate Replacements Bind to the DNA Repair Exonuclease SNM1A 

    McGouran, Joanna; Dürr, Eva-Maria; Doherty, William; Lee, Sook Y.; El-Sagheer, Afaf; Shivalingam, Arun; McHugh, Peter J.; Brown, Tom (2018)
    Phosphate groups are often crucial to biological activity and interactions of oligonucleotides, but confer poor membrane permeability. In addition, the group's lability to enzymatic hydrolysis is an obstacle to its use in ...
  • Synthesis and Evaluation of 1,2,3-Triazole-Containing Vinyl and Allyl Sulfones as Anti-Trypanosomal Agents 

    Nolan, Derek; McGouran, Joanna; Doherty, William; Adler, Nikoletta; Knox, Andrew; Nikalje, Anna Pratima; Sarkate, Aniket; Lokwani, Deepak; Evans, Paul (2017)
    An approach is described to access 1,2,3‐triazole‐derived peptidyl vinyl sulfones as Trypanosoma brucei brucei inhibitors by using click chemistry, starting from a common azide intermediate. Among the triazole analogues, ...