Browsing Zoology (Scholarly Publications) by Author "Rolfe, Rebecca"
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Abnormal fetal muscle forces result in defects in spinal curvature and alterations in vertebral segmentation and shape
Rolfe, Rebecca (2017)The incidence of congenital spine deformities, including congenital scoliosis, kyphosis, and lordosis, may be influenced by the in utero mechanical environment, and particularly by fetal movements at critical time-points. ... -
Effects of abnormal muscle forces on prenatal joint morphogenesis in mice
Rolfe, Rebecca; Murphy, Paula (2019)Fetal movements are essential for normal development of the human skeleton. When fetal movements are reduced or restricted, infants are at higher risk of developmental dysplasia of the hip and arthrogryposis (multiple joint ... -
Geometric analysis of chondrogenic self-organisation of embryonic limb bud cells in micromass culture.
Murphy, Paula; Rolfe, Rebecca (Springer Nature, 2022)Spatial and temporal control of chondrogenesis generates precise, species-specific patterns of skeletal structures in the developing vertebrate limb. The pattern-template is laid down when mesenchymal cells at the core ... -
Investigating the mechanistic basis of biomechanical input controlling skeletal development: exploring the interplay with Wnt signalling at the joint
Rolfe, Rebecca; Murphy, Paula (University of Edinburgh (datashare), 2018)Embryo movement is essential to the formation of a functional skeleton. Using mouse and chick models, we previously showed that mechanical forces influence gene regulation and tissue patterning, particularly at developing ... -
Joint development recovery on resumption of embryonic movement following paralysis
Murphy, Paula; Rolfe, Rebecca (2021)Fetal activity in utero is a normal part of pregnancy and reduced or absent movement can lead to long-term skeletal defects, such as Fetal Akinesia Deformation Sequence, joint dysplasia and arthrogryposis. A variety of ... -
Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation
Murphy, Paula; Rolfe, Rebecca (University of Edinburgh (datashare), 2020)Background: Normal skeletal development, in particular ossification, joint formation and shape features of condyles, depends on appropriate mechanical input from embryonic movement but it is unknown how such physical stimuli ... -
Mechanical Regulation of Skeletal Development
Murphy, Paula; Rolfe, Rebecca (University of Edinburgh (datashare), 2013)Development of the various components of a normal skeleton requires highly regulated signalling systems that co-ordinate spatial and temporal patterns of cell division, cell differentiation and morphogenesis. Much work in ... -
Mechanical Stimulation via Muscle Activity is Necessary for the Maturation of Tendon Multiscale Mechanics during Embryonic Development
Murphy, Paula; Rolfe, Rebecca (2021)During embryonic development, tendons transform into a hypocellular tissue with robust tensile load-bearing capabilities. Previous work suggests that this mechanical transformation is due to increases in collagen fibril ... -
Quantifying the tolerance of chick hip joint development to temporary paralysis and the potential for recovery
Rolfe, Rebecca (2021)Background: Abnormal fetal movements are implicated in joint pathologies such as arthrogryposis and developmental dysplasia of the hip (DDH). Experimentally induced paralysis disrupts joint cavitation and morphogenesis ... -
Short-term foetal immobility temporally and progressively affects chick spinal curvature and anatomy and rib development
Rolfe, Rebecca (2019)Congenital spine deformities may be influenced by movements in utero, but the effects of foetal immobility on spine and rib development remain unclear. The purpose of the present study was to determine (1) critical time-periods ... -
Techniques for Studying Mechanobiology
Rolfe, Rebecca (Elsivier, 2018)Lying at the intersection between engineering and biology, mechanobiology is a nascent field of study that investigates adaptation of the structure and behavior of tissues in response to mechanical loading. While mechanobiology ... -
Transcriptome analysis of the mouse E14.5 (TS23) developing humerus and differential expression in muscle-less mutant embryos lacking mechanical stimulation
Murphy, Paula; Rolfe, Rebecca (University of Edinburgh (datashare), 2014)Mechanical stimulation is important for the correct formation of the skeleton. Splotch-delayed mutant embryos (Pax3Spd/Spd) that develop with no limb muscle and therefore no limb movement experience an altered mechanical ...