Browsing by Subject "schizophrenia"
Now showing items 1-20 of 37
-
Acoustic and Temporal Analysis of Speech: A Potential Biomarker for Schizophrenia
(2010)Currently, there are no established objective biomarkers for the diagnosis or monitoring of schizophrenia. It has been previously reported that there are notable qualitative differences in the speech of schizophrenics. The ... -
Analysis of the hexanucleotide repeat expansion and founder haplotype at C9ORF72 in an Irish psychosis case-control sample.
(2014)The hexonucleotide repeat expansion 'GGGGCC' at the C9ORF72 gene has been strongly linked with amyotrophic lateral sclerosis and frontotemporal dementia. There is some evidence for clinical and genetic overlap between ... -
Are auditory-evoked frequency and duration mismatch negativity (MMN) deficits endophenotypic for schizophrenia? High-density electrical mapping in clinically unaffected first-degree relatives, recent-onset and chronic schizophrenia
(Elsevier, 2008)Mismatch negativity (MMN) is a negative-going event-related potential (ERP) component that occurs in response to intermittent changes in constant auditory backgrounds. A consistent finding across a large number of studies ... -
Brain vs Behavior: An Effect Size Comparison of Neuroimaging and Cognitive Studies of Genetic Risk for Schizophrenia.
(2013)Genetic variants associated with increased risk for schizophrenia (SZ) are hypothesized to be more penetrant at the level of brain structure and function than at the level of behavior. However, to date the relative sensitivity ... -
Developing pedigree-based strategies to analyse whole genome sequencing data for complex disorders: learning from schizophrenia
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Complex genetic disorders are impacted by a range of DNA variation. Next generation sequencing (NGS) allows for the direct examination of this variation, but large sample numbers are required to identify rare variants in ... -
Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia
(2008)Background: Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. ... -
Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia,
(Elsevier, 2008)Background: Variation at the dysbindin gene (DTNBP1) has been associated with increased risk for schizophrenia in numerous independent samples and recently with deficits in general and domain-specific cognitive processing. ... -
The effects of clozapine and haloperidol on astrocyte function and morphology
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2019)Schizophrenia is a chronic debilitating psychiatric disorder affecting approximately 1% of the population worldwide. The disorder is characterised by positive symptoms, negative symptoms, and clinical deficits in cognition. ... -
Epistatic and Independent Effects on Schizophrenia-Related Phenotypes Following Co-disruption of the Risk Factors Neuregulin-1 × DISC1
(2017)Few studies have addressed likely gene × gene (ie, epistatic) interactions in mediating risk for schizophrenia. Using a preclinical genetic approach, we investigated whether simultaneous disruption of the risk factors ... -
Exploring sexual and relationship possibilities for people with psychosis - a review of the literature
(2003)This review examines the literature on sex and relationship issues in the context of serious and persistent mental health problems. It identifies gaps in the research and highlights key issues needing further investigation. ... -
The expression of sexuality in people with psychosis - breaking the taboos
(2000)While mental health professionals should recognize that people suffering from schizophrenia have sexual and relationship requirements, there appears to be a failure to address adequately the subject of human sexuality, ... -
Hearing the Unheard: An Interdisciplinary, Mixed Methodology Study of Women's Experiences of Hearing Voices (Auditory Verbal Hallucinations).
(2015)This paper explores the experiences of women who "hear voices" (auditory verbal hallucinations). We begin by examining historical understandings of women hearing voices, showing these have been driven by androcentric ... -
Investigating mental health service user views regarding sexual and relationship issues
(2010)To date, very few empirical studies exist that investigate sexual and relationship issues and people who experience enduring mental health problems and less attention has been paid to the personal accounts of clients in ... -
Investigation of the genetic association between quantitative measures of psychosis and schizophrenia: a polygenic risk score analysis.
(2012)The presence of subclinical levels of psychosis in the general population may imply that schizophrenia is the extreme expression of more or less continuously distributed traits in the population. In a previous study, we ... -
Is "clinical" insight the same as "cognitive" insight in schizophrenia?
(2009)Poor insight is associated with impaired cognitive function in psychosis. Whether poor clinical insight overlaps with other aspects of self-awareness in schizophrenia, such as cognitive self-awareness, is unclear. We ... -
Microduplications of 16p11.2 are associated with schizophrenia
(Nature, 2009)Recurrent microdeletions and microduplications of a 600-kb genomic region of chromosome 16p11.2 have been implicated in childhood-onset developmental disorders. We report the association of 16p11.2 microduplications with ...