Browsing by Subject "inflammation"
Now showing items 1-20 of 20
-
Addition of a Viral Immunomodulatory Domain to Etanercept Generates a Bifunctional Chemokine and TNF Inhibitor
(2020)The inhibition of tumor necrosis factor (TNF) through the use of either antibodies or soluble receptors is a highly effective strategy for the clinical control of chronic inflammatory conditions such as rheumatoid arthritis. ... -
Autophagy and inflammatory diseases.
(2013)Autophagy is a cellular mechanism for the sequestration and degradation of intracellular pathogens and compromised organelles, particularly damaged mitochondria. Autophagy also clears other cellular components, such as ... -
Chemistry and Biology studies on anti-inflammiatory bile acid derivatives
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2019)Abstract The objective of the dissertation is to clarify the potency, cytotoxicity and metabolism of novel steroidal anti-inflammatory compounds in the treatment inflammatory bowel disease (IBD). Biochemical methods with ... -
Enhancement of chemokine function as an immunomodulatory strategy employed by human herpesviruses.
(Public Library of Science, 2012-02-02)Herpes simplex virus (HSV) types 1 and 2 are highly prevalent human neurotropic pathogens that cause a variety of diseases, including lethal encephalitis. The relationship between HSV and the host immune system is one of ... -
Exercise has persistent effects on learning and memory throught the lifespan: Analysis of the underlying mechanisms
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2018)Ageing is a complex process associated with a decline in organism functions. Ageing affects several cellular and molecular brain mechanisms and is commonly associated with decline in brain function, such as cognition and ... -
Gender and Neonatal Inflammation in Preterm Outcome
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2021)Introduction: Preterm neonates are at high risk of sepsis and sepsis-related complications. Despite the prominence of sepsis in neonatal practice, there is no consensus definition and the role of organ dysfunction in ... -
The hepatitis C virus (HCV) protein, p7, suppresses inflammatory responses to tumor necrosis factor (TNF)-α via signal transducer and activator of transcription (STAT)3 and extracellular signal-regulated kinase (ERK)-mediated induction of suppressor of cytokine signaling (SOCS)3
(2019)Viruses use a spectrum of immune evasion strategies that enable infection and replication. The acute phase of hepatitis C virus (HCV) infection is characterized by nonspecific and often mild clinical symptoms, suggesting ... -
Identification of novel innate immune mechanisms regulating oesophageal adenocarcinoma (OAC) progression and bacterial infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Inflammation is an essential immune system response to pathogens, damaged cells and stress stimuli and has an essential role in tissue repair and regeneration. The inflammatory response is the coordinated activation of ... -
IL-25 and type 2 innate lymphoid cells induce pulmonary fibrosis.
(2014)Disease conditions associated with pulmonary fibrosis are progressive and have a poor long-term prognosis with irreversible changes in airway architecture leading to marked morbidity and mortalities. Using murine models ... -
Inflammatory markers of antipsychotic weight gain and cardiometabolic dysfunction in youth mental health disorders
Second generation antipsychotics (SGAs) are used in children and adolescents to treat psychotic symptoms in Early Onset Psychosis (EOP) and irritability and behaviours that challenge in autism spectrum disorder (ASD). ... -
Influenza A virus causes maternal and fetal pathology via innate and adaptive vascular inflammation in mice.
(2020)Influenza A virus (IAV) infection during pregnancy causes severe maternal and perinatal complications, despite a lack of vertical transmission of IAV across the placenta. Here, we demonstrate a significant alteration in ... -
The interactions of apolipoprotein E and inflammation in human iPSC-derived astrocytes
(Trinity College Dublin. School of Medicine. Discipline of Physiology, 2020)Alzheimer’s disease (AD) is a devastating neurodegenerative disease characterised histologically by the presence of extracellular plaques and intracellular neurofibrillary tangles, and clinically by memory ... -
An investigation into molecular biomarkers of pulp inflammation and cell death and their potential use as a diagnostic tool.
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2024)The overarching aim of the thesis was to present a robust method of collecting and analysing pulpal blood, to inform quality biomarker discovery with the potential to detect the `threshold? between teeth amenable to vital ... -
Metabolism of inflammation limited by AMPK and pseudo-starvation.
(2013)Metabolic changes in cells that participate in inflammation, such as activated macrophages and T-helper 17 cells, include a shift towards enhanced glucose uptake, glycolysis and increased activity of the pentose phosphate ... -
MyD88 adaptor-like (Mal) regulates intestinal homeostasis and colitis-associated colorectal cancer in mice.
(2014)Toll-like receptors (TLRs) play a central role in the recognition and response to microbial pathogens and in the maintenance and function of the epithelial barrier integrity in the gut. The protein MyD88 adaptor-like ... -
PAEDIATRIC OUTCOMES AND SERUM BIOMARKER PANEL IN ACUTE TRAUMATIC BRAIN INJURY /CONCUSSION TO SEVERE TRAUMATIC BRAIN INJURY
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction Paediatric mild traumatic brain injury (mTBI) is increasingly recognised to have significant longer term neurocognitive effects. Childhood is a time of high risk for head injury. There were no national ... -
Succinate: a metabolic signal in inflammation
(2013)Succinate is an intermediate of the tricarboxylic acid (TCA) cycle, and plays a crucial role in adenosine triphosphate (ATP) generation in mitochondria. Recently, new roles for succinate outside metabolism have emerged. ... -
The TLR signaling adaptor TRAM interacts with TRAF6 to mediate activation of the inflammatory response by TLR4.
(2014)TLRs act as sentinels in professional immune cells to detect and initiate the innate immune response to pathogen challenge. TLR4 is a widely expressed TLR, responsible for initiating potent immune responses to LPS. TRAM ... -
Worsening Cognitive Impairment and Neurodegenerative Pathology Progressively Increase Risk for Delirium.
(2015)Background Delirium is a profound neuropsychiatric disturbance precipitated by acute illness. Although dementia is the major risk factor this has typically been considered a binary quantity (i.e., cognitively impaired ...