Browsing by Subject "cancer"
Now showing items 1-12 of 12
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Chemotherapeutic compounds targeting the DNA double-strand break repair pathways: the good, the bad, and the promising.
(2014)The repair of DNA double-strand breaks (DSBs) is a critical cellular mechanism that exists to ensure genomic stability. DNA DSBs are the most deleterious type of insult to a cell’s genetic material and can lead to genomic ... -
The development, implementation and evaluation of frailty assessment in oncology
(Trinity College Dublin. School of Medicine. Discipline of Radiation Therapy, 2020)Over the last number of decades, treatment outcomes from cancer care have improved dramatically. However, these improvements have mostly benefitted younger patients, or relatively robust older adults, rather than the entire ... -
Examining the impact of a social prescribing service on the health & wellbeing of individuals living with and beyond cancer
(Trinity College Dublin. School of Medicine. Discipline of Occupational Therapy, 2020)Social prescribing is a community-based intervention that supports individuals with health needs and chronic conditions to access activities supports in their community. Due to medical improvements, more people than ever ... -
Functions and therapeutic roles of exosomes in cancer.
(2014)The role of exosomes in cancer development has become the focus of much research, due to the many emerging roles possessed by exosomes. These micro-vesicles that are ubiquitously released in to the extracellular milieu, ... -
Interventions for promoting participation in shared decision-making for children with cancer [protocol]
(2011)This is the protocol and there is no abstract. The objectives are as follows: To examine the effects of interventions to promote shared decision-making (SDM) for children with cancer who are aged four to 18 years. -
Targeting nuclear factor-kappa B to overcome resistance to chemotherapy.
(2013)Intrinsic or acquired resistance to chemotherapeutic agents is a common phenomenon and a major challenge in the treatment of cancer patients. Chemoresistance is defined by a complex network of factors including multi-drug ... -
Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment.
(2014)The immune system has a key role to play in controlling cancer initiation and progression. T cell activation, which is central to anti-tumor immune responses, coincides with changes in cellular metabolism. Naïve T cells ... -
Three-dimensional (3D) hepatic cell culture models to improve the clinical translation of nanobiomaterials (NBMs)
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2021)Despite the wide-reaching applications of nanoparticles that may be used for medical applications, i.e. nanobiomaterials or NBMs, in human health and medicine, their translation to the clinic is staggering slow, with a ... -
Trends and Patterns in Cancer Mortality in Northern Ireland
(Statistical and Social Inquiry Society of Ireland, 2010)Cancer is a major public health issue in Northern Ireland with one in three of the population developing some form of the disease by the time they reach 75 years. However in many ways cancer is a misunderstood disease with ... -
Understanding the role of accessory components in regulation of the Polycomb Repressive Complex 2 in mESCs and cancer
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2022)Polycomb Repressive Complex 2 is a chromatin regulatory complex composed of core subunits EZH1/2, EED, SUZ12 and RBBP4/7, around which several accessory components assemble in a mutually exclusive manner to form structurally ...