Browsing by Subject "Whole-genome sequencing"
Now showing items 1-9 of 9
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Contribution of whole-genome sequencing to understanding of the epidemiology and control of meticillin-resistant Staphylococcus aureus
(2019)In recent years, approaches to tracking the spread of meticillin-resistant Staphylococcus aureus (MRSA) as part of outbreak management have used conventional DNA-based methods, including pulsed-field gel electrophoresis ... -
Epidemiological and Phylogenetic Investigation of Panton-Valentine Leukocidin-Positive Community-Associated Methicillin-Resistant Staphylococcus aureus in Ireland and Internationally using Whole-Genome Sequencing
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2023)Methicillin-resistant Staphylococcus aureus (MRSA) is a successful modern pathogen associated with many clinical manifestations including asymptomatic colonisation, superficial skin infections and severe invasive diseases. ... -
An Investigation of the Prevalence, Population Structure and Relatedness of Environmental, Healthcare Worker and Patient Staphylococcus aureus Isolates Recovered from Multi-bed Patient Rooms in an Irish Teaching hospital by Whole-Genome Sequencing
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2020)The putative role of the air in Staphylococcus aureus transmission in multi-bed ward areas of hospitals, where the majority of in-patients are cared for, has not yet been elucidated. The work described in this thesis ... -
METICILLIN-RSISTANT Staphylococcus aureus TRANSMISSION AMONG HEALTHCARE WORKERS, PATIENTS AND THE ENVIRONMENT IN A LARGE ACUTE HOSPITAL UNDER NON-OUTBREAK CONDITIONS INVESTIGATED BY WHOLE-GENOME SEQUENCING
(2021)Background: The role of meticillin-resistant Staphylococcus aureus (MRSA) colonization of healthcare workers (HCWs), patients and the hospital environment in MRSA transmission in non-outbreak settings is poorly understood. Aims: ... -
Meticillin-susceptible Staphylococcus aureus transmission among healthcare workers, patients and the environment in a large acute hospital under non-outbreak conditions investigated using whole-genome sequencing
(2022)Background: The role of meticillin-susceptible Staphylococcus aureus (MSSA) colonization of healthcare workers (HCWs), patients and the hospital environment in MSSA transmission events (TEs) is poorly understood. Aims: ... -
MULTIPLE DISTINCT OUTBREAKS OF PANTON-VALENTINE LEUKOCIDIN (PVL)-POSITIVE COMMUNITY-ASSOCIATED METHICILLIN-RESISTANT Staphylococcus aureus (CA-MRSA) IN IRELAND INVESTIGATED BY WHOLE-GENOME SEQUENCING
(2021)Background: Panton–Valentine leucocidin (PVL)-positive community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) is increasingly associated with infection outbreaks. Aim: To investigate multiple suspected ... -
A novel multidrug-resistant PVL-negative CC1-MRSA-1 IV clone emerging in Ireland and Germany likely originated in South-Eastern Europe
(2019)This study investigated the recent emergence of multidrug-resistant Panton-Valentine leukocidin (PVL)-negative CC1-MRSA-IV in Ireland and Germany. Ten CC1-MSSA and 139 CC1-MRSA isolates recovered in Ireland between 2004 ... -
The Population Structure and Mobile Genetic Elements Harboured by Hospital-Adapted Vancomycin-Resistant and Linezolid-Resistant Enterococcus faecium and Enterococcus faecalis in Ireland Investigated by Whole-Genome Sequencing
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2021)Vancomycin-resistant enterococci (VRE) are a major cause of healthcare-associated infection worldwide. For over a decade, Ireland has consistently had some of the highest rates of invasive VRE infections in Europe. VRE ... -
Whole-genome sequencing identifies highly related Pseudomonas aeruginosa strains in multiple washbasin U-bends at several locations in one hospital: evidence for trafficking of potential pathogens via wastewater pipes
(2020)Background: Hand washbasin U-bends have increasingly been associated with nosocomial outbreaks by Gram-negative bacteria, including Pseudomonas aeruginosa which is virtually ubiquitous in U-bends. Wastewater networks ...