Browsing by Subject "Tissue engineering"
Now showing items 1-20 of 28
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Biofabrication of multiscale bone extracellular matrix scaffolds for bone tissue engineering
(2019)Interconnected porosity is critical to the design of regenerative scaffolds, as it permits cell migration, vascularisation and diffusion of nutrients and regulatory molecules inside the scaffold. 3D printing is a promising ... -
Characterization of extracellular matrix modified poly(¿-caprolactone) electrospun scaffolds with differing fiber orientations for corneal stroma regeneration
(2020)Alternatives to donor cornea transplantation based on tissue engineering are desirable to overcome the current severe donor tissue shortage. Many natural polymers have good biological properties but poor mechanical properties ... -
Collagen/pristine graphene as an electroconductive interface material for neuronal medical device applications
(2022)The growing clinical demand for electrical stimulation-based therapies requires the development of novel conductive biomaterials that balance conductivity, biocompatibility, and mechanical performance. Traditional conductive ... -
Decellularization and recellularization of cornea: Progress towards a donor alternative.
(2020)The global shortage of donor corneas for transplantation has led to corneal bioengineering being investigated as a method to generate transplantable tissues. Decellularized corneas are among the most promising materials ... -
Designing Scaffolds for Corneal Regeneration
(2020)Corneal blindness is one of the most common causes of vision loss worldwide, affecting millions of people. To treat these patients, researchers have been examining different approaches to engineer corneal scaffolds suitable ... -
Development of a New Bone¿Mimetic Surface Treatment Platform: Nanoneedle Hydroxyapatite (nnHA) Coating
(2020)The hierarchical structure of bone plays pivotal roles in driving cell behavior and tissue regeneration and must be considered when designing materials for orthopedic applications. Herein, it is aimed to recapitulate the ... -
The effect of pore size within fibrous scaffolds fabricated using melt electrowriting on human bone marrow stem cell osteogenesis.
(2019)Limitations associated with current bone grafting materials has necessitated the development of synthetic scaffolds that mimic the native tissue for bone repair. Scaffold parameters such as pore size, pore interconnectivity, ... -
Engineering a Corneal Stromal Equivalent Using a Novel Multilayered Fabrication Assembly Technique.
(2020)To overcome the serious shortage of donor corneas for transplantation, alternatives based on tissue engineering need to be developed. Decellularized corneas are one potential alternative, but their densely packed collagen ... -
Engineering innate immunology in cardiovascular disease models and regenerative medicine
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)Heart failure is the leading cause of death worldwide with atherosclerosis and myocardial infarction remaining prominent causes. It is now widely accepted that the inflammatory response holds a key role in advancing both ... -
Fabrication and biocompatibility of electroconductive silk fibroin/pedot: Pss composites for corneal epithelial regeneration
(2020)The aim of this study was to develop matrices that can support human corneal epithelial cells and innervation by incorporating a conducting polymer, poly(3,4-ethylenedioxythiophene) poly(styrene sulfonate) (PEDOT:PSS), ... -
Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering
(2019)Extracellular matrix (ECM)-derived implants hold great promise for tissue repair, but new strategies are required to produce efficiently decellularized scaffolds with the necessary porosity and mechanical properties to ... -
Harnessing the innate and adaptive immune system for tissue repair and regeneration: Considering more than macrophages
(2021)Tissue healing and regeneration is a complex, choreographed, spatiotemporal process involving a plethora of cell types, the activity of which is stringently regulated in order for effective tissue repair to ensue post ... -
Hydrogels: Soft matters in photomedicine
(2019)Photodynamic therapy (PDT), a shining beacon in the realm of photomedicine, is a non‐invasive technique that utilizes dyebased photosensitizers (PSs) in conjunction with light and oxygen to produce reactive oxygen species ... -
The impact of decellularization methods on extracellular matrix derived hydrogels.
(2019)Tissue-derived decellularized biomaterials are ideal for tissue engineering applications as they mimic the biochemical composition of the native tissue. These materials can be used as hydrogels for cell encapsulation and ... -
Integrating finite element modelling and 3D printing to engineer biomimetic polymeric scaffolds for tissue engineering
(2019)The suitability of a scaffold for tissue engineering is determined by a number of interrelated factors. The biomaterial should be biocompatible and cell instructive, with a porosity and pore interconnectivity that facilitates ...