Browsing by Subject "Tissue Engineering"
Now showing items 1-13 of 13
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3D Bioprinting Strategies To Engineer Structurally Organised Meniscal Tissue Grafts
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)Lesions to the meniscus are common sports-related injuries that can lead to articular cartilage degeneration and osteoarthritis if left untreated. While surgical repair procedures and meniscal substitutes offer better ... -
BIOFABRICATION STRATEGIES TO GUIDE THE SELF-ORGANISATION OF BIOMIMETIC CARTILAGE AND OSTEOCHONDRAL TISSUES
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2021)The modest clinical impact of musculoskeletal tissue engineering (TE) can be attributed, at least in part, to a failure to recapitulate the structure, composition and functional properties of the target tissue. This has ... -
Controlled release of transforming growth factor-?3 from cartilage-extra-cellular-matrix-derived scaffolds to promote chondrogenesis of human-joint-tissue-derived stem cells.
(2014)Abstract: The objective of this study was to develop a scaffold derived from cartilaginous extracellular matrix (ECM) that could be used as a growth factor delivery system to promote chondrogenesis of stem cells. ... -
Non-Invasive metabolic profiling in tissue engineering and innate immunology by 2P-FLIM
(Trinity College Dublin. School of Engineering. Discipline of Mechanical & Manuf. Eng, 2023)During the golden age of biochemistry from 1920s to 1960s, many of the metabolic pathways responsible for nutrient usage and energy production in humans and other organisms was defined. During this period, glycolysis, Krebs ... -
Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors
(2021)Regenerating large bone defects remains a significant clinical challenge, motivating increased interest in additive manufacturing and 3D bioprinting to engineer superior bone graft substitutes. 3D bioprinting enables ... -
Tissue engineering whole bones through endochondral ossification: Regenerating the distal phalanx
(2015)Novel strategies are urgently required to facilitate regeneration of entire bones lost due to trauma or disease. In this study, we present a novel framework for the regeneration of whole bones by tissue engineering ...