Browsing by Subject "TLR2"
Now showing items 1-3 of 3
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α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
(2015)The immunoregulatory function of single-Ig-interleukin-1 related receptor (SIGIRR) is derived from its ability to constrain the inflammatory consequences of interleukin (IL)-1R and toll-like receptor (TLR)4 activation. ... -
Identification of novel innate immune mechanisms regulating oesophageal adenocarcinoma (OAC) progression and bacterial infection
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Inflammation is an essential immune system response to pathogens, damaged cells and stress stimuli and has an essential role in tissue repair and regeneration. The inflammatory response is the coordinated activation of ... -
Inflammasome Involvement in Barrett's and Oesophageal Adenocarcinoma
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Barrett's oesophagus is an inflammatory condition and a neoplastic precursor to oesophageal adenocarcinoma (OAC). Inflammasome signalling pathways contribute to acute and chronic inflammation, and can be enhanced by obesity. ...