Browsing by Subject "T-cells"
Now showing items 1-5 of 5
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Adenosine-mono-phosphate-activated protein kinase-independent effects of metformin in T cells.
(2014)The anti-diabetic drug metformin regulates T-cell responses to immune activation and is proposed to function by regulating the energy-stress-sensing adenosine-monophosphate-activated protein kinase (AMPK). However, the ... -
Advances in siRNA delivery to T-cells: potential clinical applications for inflammatory disease, cancer and infection.
(2013)The specificity of RNAi and its ability to silence 'undruggable' targets has made inhibition of gene expression in T-cells with siRNAs an attractive potential therapeutic strategy for the treatment of inflammatory disease, ... -
The alarmin IL-33 promotes regulatory T-cell function in the intestine.
(2014)FOXP3(+) regulatory T cells (Treg cells) are abundant in the intestine, where they prevent dysregulated inflammatory responses to self and environmental stimuli. It is now appreciated that Treg cells acquire tissue-specific ... -
Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.
(2013)Suppressor of cytokine signaling (SOCS) proteins are key regulators of CD4+ T cell differentiation, and in particular, we have recently shown that SOCS2 inhibits the development of Th2 cells and allergic immune responses. ... -
Sphingosine-1-phosphate receptor modulator FTY720 attenuates experimental myeloperoxidase-ANCA vasculitis in a T cell-dependent manner
(2020)Sphingosine-1-phosphate (S1P) is a pleiotropic lysosphingolipid derived from the metabolism of plasma membrane lipids. The interaction between S1P and its ubiquitously expressed G-protein-coupled receptors (S1PR1-5) is ...