Browsing by Subject "Skeletal development"
Now showing items 1-5 of 5
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Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis
(University of Edinburgh (datashare), 2011)In genetically modified mice with abnormal skeletal muscle development, bones and joints are differentially affected by the lack of skeletal muscle.We hypothesise that unequal levels of biophysical stimuli in the ... -
Joint development recovery on resumption of embryonic movement following paralysis
(2021)Fetal activity in utero is a normal part of pregnancy and reduced or absent movement can lead to long-term skeletal defects, such as Fetal Akinesia Deformation Sequence, joint dysplasia and arthrogryposis. A variety of ... -
Localization of YAP activity in developing skeletal rudiments is responsive to mechanical stimulation
(University of Edinburgh (datashare), 2020)Background: Normal skeletal development, in particular ossification, joint formation and shape features of condyles, depends on appropriate mechanical input from embryonic movement but it is unknown how such physical stimuli ... -
Mechanical Regulation of Skeletal Development
(University of Edinburgh (datashare), 2013)Development of the various components of a normal skeleton requires highly regulated signalling systems that co-ordinate spatial and temporal patterns of cell division, cell differentiation and morphogenesis. Much work in ...