Browsing by Subject "Pharmacology, Ph.D."
Now showing items 1-16 of 16
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An investigation into the behavioural effects of polyamines, polyamine antagonsits and novel compounds in vivo
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The polyamines, putrescine, spermidine and spermine are ubiquitous compounents of eukaryotric cells in nature and are found in high concentrations in brain tissue. Polyamines have been implicated in cell growth, differentiation ... -
An investigation into the effects of current immunosuppressants and novel compounds on animal models of asthma and delayed type hypersensitivity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)Asthma is a disease with a worldwide distribution and of increasing prevalence. There are two forms of the disease; intrinsic, which is believed to follow a Th1 cytokine profile and extrinsic, which follows a Th2 response. ... -
An investigation of the role of the polyamines in epilepsy and cerebral ischaemia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)The polyamines, spermine and spermidine, are ubiquitous in nature but are found in especially high concentrations in brain tissue. The polyamines are required for cell growth and differentiation but in high doses are ... -
An investigation on the therapeutic properties of novel compounds in models of asthma, inflammation and delayed type hypersensitivity
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)There are many drugs on the market for the treatment of asthma, inflammation and delayed type hypersensitivity (DTH), however few are disease modifying. The potential therapeutic effect of three novel compounds, 3C8, 6C6 ... -
Assessment of arterial stiffness using oscillometric arteriography
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2009)The present series of studies examined whether an oscillometric method (Arteriograph), which measures arterial stiffness indices, pulse wave velocity (PWV m/sec), and wave reflection as augmentation index [Alx %], is on ... -
Blood biocompatiblity of polyvinyl, chloride surface-modified with multi-walled carbon nanotubes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2012)Blood-surface interaction in extracorporeal circuits (for example, cardiopulmonary bypass) requires the infusion of a systemic anticoagulant to prevent devastating thrombus formation. Platelet activation upon contact with ... -
Genetic polymorphisms and arterial stiffness
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)Arterial stiffness exerts a major influence on cardiac afterload and coronary perfusion. Indices of arterial stiffness have therefore been proposed as surrogate markers of cardiovascular risk and as potential therapeutic ... -
Hormonal and emotional regulation of memory processes
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This thesis comprises two areas of study. The first study examined the effect of the menstrual cycle on Event-Related Potentials (ERPs) and verbal memory, as measured by paragraph recall and paired associates, and mood, ... -
Nitrate-barbiburate compounds inhibit matrix metalloproteinase-9 in in-vitro and in-vivo models of intestinal inflammation
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2014)Inflammatory bowel disease is characterised by a dysregulated immune response and a compromised epithelial barrier. The enzyme matrix metalloproteinase-9 (MMP-9) is upregulated in an inflammatory setting and is believed ... -
Pharmacologically induced long-term enhancement in the hippocampus in vivo
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2007)The present study investigated the mechanisms underlying a pharmacologically induced long-term enhancement (LTE) of fast excitatory synaptic transmission in the CA1 region of the rat hippocampus in vivo. The role of ... -
Platelets decrease chemotherapy -induced cancer cell damage by increasing cell survival : mechanisms and significance
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Cancer cells grow without the restraints of feedback control mechanisms that regulate normal tissue or organ growth, such as apoptosis, leading to Increased cancer cell survival. Deregulation of apoptosis has been Implicated ... -
Polyamines and polyamine antagonists in cerebral ischaemia
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)Polyamines are ubiquitous components of all eukaryotic cells and are found in brain tissue. A number of studies have shown that changes in the levels of polyamines occur following cerebral ischaemia. However, whether ... -
RBL-2H3 and primary mast cells and their use in screening novel anti-inflammatory compounds
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)Mast cells (MC) have been mainly studied as key effectors in allergic diseases and inflammatory conditions such hypersensitivity reactions, asthma, atopic dermatitis and multiple sclerosis. Following the crosslinkage of ... -
Synaptic plasticity in animal models of stress : serotonergic mechanisms
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2005)The inhibitory effect of acute elevated platform stress exposure on synaptic plasticity in the CA1 region of the hippocampus in vivo was investigated. Such stress exposure was confirmed to inhibit subsequent long term ... -
Synthetic amorphous silica nanoparticles induce human endothelial cell inflammation and platelet aggregation : role of NF-kB and reactive nitrogen species
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Background and purpose: The human population has been exposed to nanoparticles (particles with nano-dimensions) throughout all its evolutionary process; however, this exposure has been increased since the industrial ... -
The synthesis and biological evaluation of a novel class of butyrylcholinesterase inhibitors using isosorbide as a building block
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2007)The aim of this project was to synthesise and optimise a novel class of cholinesterase inhibitors using the simple sugar, isosorbide, as a building block and to assess the inhibitory activity of these compounds in vitro. ...