Browsing by Subject "Pharmaceutics, Ph.D."
Now showing items 1-20 of 28
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A study of the release of the amphoteric drug amoxycillin from biodegradable polymers
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Poly-alpha-hydroxy-aliphatic esters constitute a group of biodegradable polymers which have been actively investigated over the past three decades for the sustained release of drug compounds. A literature review revealed ... -
Absorption properties of non-steroidal anti-inflammatory drugs and their amino acid derivatives
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The principal objectives of this work were: i) to examine the absorption properties of ibuprofen in a range of different buffer solutions; ii) to study the absorption properties and mechanisms of ibuprofen, ketoprofen and ... -
Assessment of permeability enhancers for salmon calcitonin (sCT) across intestinal cell culture models
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)A large number of proteins are now being used or tested as therapeutic agents, enzyme inhibitors or antibodies to combat human disease, therefore they are receiving increased recognition for both their high activity at low ... -
Characterisation of drug-fatty acid composites and their use in drug delivery systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Fatty acids are considered to be useful as carrier materials in the formulation of drug delivery systems. Literature on fatty acid systems, in particular, stearic acid, was reviewed, though in general, research in this ... -
Development of salmon calcitonin (sCT) nanoporous / nanoparticulate microparticles for pulmonary delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis focus on the development and production by spray drying of porous microparticulate systems designed for the pulmonary delivery of a therapeutic peptide - salmon calcitonin. The nanoporous/nanoparticulate ... -
Factors affecting the pharmacotherapeutic management of chronic non-malignant pain in ageing and elderly populations in Ireland
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Chronic non-malignant pain (CNMP) has emerged as a global health priority due to the prevalence, complexity and presentation of the condition across all age- groups, social classes and ethnicities. There is a high prevalence ... -
Formulation of protein and DNA microparticulate vaccine systems
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)This study involved investigation of protein and DNA-loaded microspheres manufactured with a range of polymers and under different manufacturing conditions. The polymers used during encapsulation were poly (lactide-co-glycolide) ... -
Formulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The current study involved the preparation of a range of micro and nano particulates from known biocompatible pharmaceutical polymeric excipients: PLGA, chitosan and hyaluronic acid, using physical rather than chemical ... -
Intestinal degradation and absorption kinetics of salmon calcitonin
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)The aim of this work was to investigate the intestinal degradation and absorption of a hydrophilic peptide, salmon calcitonin (sCT), and to evaluate the use of bile salt simple and mixed micellar systems as potential ... -
Intestinal lymphatic transport of DDT and Saquinavir : the role of lipid based formulations and modulators of P-Glycoprotein and Cytochrome P450
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)The experiments in this thesis represent biopharmaceutical investigations, performed in an attempt to evaluate potential dosage form strategies designed to promote the intestinal lymphatic transport of lipophilic compounds. ... -
Investigation of factors affecting dissolution under biorelevant low velocity hydrodynamic conditions, using in vitro and in-silico methods
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2011)The goals of the current study were to investigate the effect of hydrodynamics on the dissolution of non-disintegrating compacts in a low velocity environment. This work also studies the impact of hydrodynamics on the ... -
Investigation of ibuprofen release from ethylcellulose matrix compacts
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2004)A comprehensive study of ethylcellulose powder and ethylcellulose compacts (of different ethylcellulose viscosity grades) was undertaken. Studies showed that the lower viscosity grade ethylcellulose (4 cP) was more ... -
Investigation of the solid-state, powder flow and tabletability properties of comminuted active pharmaceutical ingredients
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)An understanding of the effect of processing on the solid-state properties of active pharmaceutical ingredients (APIs) is essential for product manufacturing success. During product development it is possible to induce ... -
Investigations of a spray-drying method for producing nanoporous / nano-particulate microparticles (NPMPs) of proteins and protein-excipient composites
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The research, presented in this thesis, concerns the application of a spray-drying method to produce nanoporous/nano-particulate microparticles (NPMPs) of proteins, stabilising excipients and composites. The proposed method, ... -
Investigations of physicochemical properties of spray dried drug-excipient composites directed to inhalable products
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2005)The studies in this thesis explored the solid state and inhalation properties of various systems produced by the spray drying technique. The work focused on the feasibility analysis of spray drying as a means of producing ... -
Mechanistic aspects of the degradation and drug release properties of poly-alpha-hydroxyl aliphatic ester nano- and microparticle
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2000)Particulate systems based on the polymers of lactic and glycolic acids have been extensively investigated as drug delivery technologies, particularly as vehicles to achieve controlled release. The release kinetics from ... -
Mechanistics aspects of the release of drugs from hydrophilic polymer matrices
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)Hydrophilic polymers, which both swell and erode, are widely used to produce sustained release of drugs from monolithic matrices, and have been extensively reviewed in the literature (Alderman 1984), (Peppas and Korsmeyer ... -
Pharmaceutical services for patients in methadone treatment in Ireland and the introduction of the Methadone Protocol Scheme
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2002)Methadone is a long-acting opiate commonly used in substitution therapy for heroin addiction. In Ireland, prior to 1998, people requiring treatment for opiate addiction could either attend the National Drug Treatment Centre, ... -
Physiochemical studies of diclofenac salts and the effect of basis excipients on their dissolution
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2001)This study involved investigation of the physicochemical properties of diclofenac salts prepared from a range of organic bases. The salts examined included five novel salts of diclofenac, prepared from the following bases: ... -
Preparation and characterisation of spray dried composites of pharmaceutical materials
(Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2003)The solid state properties of a range of spray dried excipients and drugs and co-spray dried excipient/excipient, drug/excipient and drug/drug, systems were investigated. The excipients investigated were lactose, polyethylene ...