Browsing by Subject "NK cells"
Now showing items 1-8 of 8
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IFNL cytokines do not modulate human or murine NK cell functions
(2014)The interferon-lambda (IFNL) cytokines have been shown to be important in HCV infection with SNPs in the IFNL3 gene associated with both natural and treatment induced viral clearance. We have recently shown that rs1299860 ... -
Innate IFN-gamma promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages.
(2014)The role of IFN-γ in the pathogenesis of autoimmune diseases is controversial. Although Th1 cells can induce experimental autoimmune encephalomyelitis (EAE), IFN-γ can suppress Th17 cells that are pathogenic in EAE. Here ... -
NK cell function and metabolism in human cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Natural Killer (NK) cells are important anti-cancer innate immune cells. They are essential for cancer immunosurveillance and their activity is associated with better outcome in cancer patients. Some of their key ... -
NK Cell Metabolism and TGFβ – Implications for Immunotherapy
(2019)NK cells are innate lymphocytes which play an essential role in protection against cancer and viral infection. Their functions are dictated by many factors including the receptors they express, cytokines they respond to ... -
NK cells in childhood obesity are activated, metabolically stressed, and functionally deficient
(2017)Childhood obesity is a major global concern, with over 50 million children now classified as obese. Obesity has been linked to the development of numerous chronic inflammatory diseases, including type 2 diabetes and multiple ... -
NK1.1 receptor ligation or tumour interactions prime NK cells for IL2-mediated metabolic and functional responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2019)Natural Killer (NK) cells undergo a distinct metabolic response following cytokine stimulation, which involves increased rates of glycolysis and oxidative phosphorylation (OxPhos). This metabolic response is essential for ... -
Persistent Changes in Circulating and Intestinal gamma delta T Cell Subsets, Invariant Natural Killer T Cells and Mucosal-Associated Invariant T Cells in Children and Adults with Coeliac Disease
(2013)Coeliac disease is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals. The only current therapy is a lifelong gluten free diet. While ... -
PKM2 regulation of metabolism but not transcription is important for natural killer cell responses
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2020)Natural Killer (NK) cells have an important role in immune responses to viruses and tumours. Integrating signal transduction and cellular metabolism is essential for effective NK cells responses. The PKM2 isoform of the ...