Browsing by Subject "Mycology and fungal pathogenesis"
Now showing items 1-4 of 4
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Alcohol consumption modulates Candida albicans-induced oral carcinogenesis and progression
(2023)Objectives: This study aimed to determine the impact of low levels of alcohol consumption on the interaction of the oral cavity with Candida albicans, a species that is commonly found at higher levels in the oral cavities ... -
Deletion of the Candida albicans TLO gene family using CRISPR-Cas9 mutagenesis allows characterisation of functional differences in ¿-, ß- and ¿- TLO gene function.
(2023)The Candida albicans genome contains between ten and fifteen distinct TLO genes that all encode a Med2 subunit of Mediator. In order to investigate the biological role of Med2/Tlo in C. albicans we deleted all fourteen TLO ... -
Telomeric ORFs (TLOs) in Candida spp. encode Mediator subunits that regulate distinct virulence traits
(2014)The TLO genes are a family of telomere-associated ORFs in the fungal pathogens Candida albicans and C. dubliniensis that encode a subunit of the Mediator complex with homology to Med2. The more virulent pathogen C. albicans ... -
Telomeric ORFS in Candida albicans : Does Mediator Tail Wag the Yeast?
(2015)Recent studies of fungal genomes have shown that subtelomeric regions of chromosomes are areas of rapid evolution that facilitate adaptation to novel niches [1]. Several years ago, analysis of the genome of the human ...