Browsing by Subject "Medicine, Ph.D."
Now showing items 1-8 of 8
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Alternative therapeutics for oesophageal cancer : novel toxic bile acid derivatives to induce apoptosis and siRNA library screen to identify genes that regulate cell shape
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Oesophageal adenocarcinoma (OAC) is the sixth leading cause of cancer-related deaths worldwide, and has proven most challenging for surgeons as less than a third of patients are suitable for surgical resection due to ... -
Characterisation of a mutant mouse model of spontaneous atopic dermatitis
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2017)Atopy is Immunoglobulin-E sensitisation to “allergens” such as pollen and food. Atopic dermatitis is a pruritic eczematous dermatitis associated with an early onset in infants. Atopic dermatitis has a complex pathology and ... -
Evaluation of novel biomarkers in the detection of chemotherapy-mediated cardiac and kidney injury
(Trinity College (Dublin, Ireland). Department of Physiology, 2015)Chemotherapeutic agents are associated with a risk for potential cardiac and kidney injury, however diagnostic techniques currently used to assess cardiac function lack sensitivity, whilst those used to evaluate kidney ... -
Hepatitis B, Hepatitis C and HIV in the Irish prisoner population : an overview of prevalence rates and risk factors
(Trinity College (Dublin, Ireland). Department of Public Health and Primary Care, 2002)Introduction: This thesis reports the estimated prevalence of antibodies to hepatitis B core antigen, hepatitis C virus and HIV in two distinct prison populations. -- Objective: This thesis provides a synthesised analysis ... -
How three policies aimed at increasing for-profit hospital care become an accepted method of reform in Ireland between 2000 and 2005 : 'How many ditches do you die on? '
(Trinity College (Dublin, Ireland). School of Medicine. Centre of Health Policy and Management, 2013) -
Regulators of inflammation and innate immunity identified in oesophageal cancer cell viability through implementation of a druggable genome siRNA library screen
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2015)Inflammation initiated by gastroesophageal reflux disease (GORD) can lead to development of oesophageal adenocarcinoma (OAC), through a premalignant lesion, Barrett's oesophagus (BO). OAC has a 5-year survival of patients ... -
Targeting the noradrenergic system for anti-inflammatory and neuroprotective actions in an animal model of Parkinson's disease
(Trinity College (Dublin, Ireland). Department of Physiology, 2015)Parkinson's disease (PD) is a common neurodegenerative disorder that is characterised by the selective loss of dopamine (DA) neurons within the substantia nigra pars compacta and results in reduced striatal DA input ... -
The use of the General Medical Services prescription database for pharmacoepidemiological studies in Ireland
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2003)Pharmacoepidemiology may be divided into three main subdivisions, namely pharmacovigilence, drug utilisation and prescribing quality. An aim of this thesis was to demonstrate the usefulness of the General Medical Services ...