Browsing by Subject "MRSA"
Now showing items 1-18 of 18
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The activation of unconventional T cells by Staphylococcus aureus
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2021)Staphylococcus aureus is a major human pathogen of multiple tissue sites. The emergence of antibiotic-resistant strains promises greater morbidity in the future. No S. aureus vaccine has so far succeeded in translating ... -
AIR AND SURFACE CONTAMINATION PATTERNS OF METHICILLIN-RESISTANT Staphylococcus aureus ON EIGHT ACUTE HOSPITAL WARDS
(2014)BACKGROUND. Methicillin-resistant Staphylococcus aureus (MRSA) can be recovered from hospital air and from environmental surfaces. This poses a potential risk of transmission to patients. OBJECTIVE. To investigate ... -
Contribution of whole-genome sequencing to understanding of the epidemiology and control of meticillin-resistant Staphylococcus aureus
(2019)In recent years, approaches to tracking the spread of meticillin-resistant Staphylococcus aureus (MRSA) as part of outbreak management have used conventional DNA-based methods, including pulsed-field gel electrophoresis ... -
DETECTION OF STAPHYLOCOCCAL CASSETTE CHROMOSOME mec Type XI ENCODING HIGHLY DIVERGENT mecA, mecI, mecR1, blaZ and ccr GENES IN HUMAN CLINICAL CLONAL COMPLEX 130 METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS
(2011)Methicillin resistance in staphylococci is mediated by penicillin binding protein 2a (PBP2a) encoded by mecA on mobile staphylococcal cassette chromosome mec (SCCmec) elements. In this study two clonal complex (CC) 130 ... -
Emergence of Sequence Type 779 Methicillin-Resistant Staphylococcus aureus (MRSA) Harboring a Novel Pseudo Staphylococcal Cassette Chromosome mec (SCCmec)-SCC-SCCCRISPR Composite Element in Irish Hospitals.
(2013)Methicillin-resistant Staphylococcus aureus (MRSA) has been a major cause of nosocomial infection in Irish hospitals for 4 decades, and replacement of predominant MRSA clones has occurred several times. An MRSA isolate ... -
AN EMERGING PANTON-VALENTINE (PVL)-POSITIVE CC5-METICILLIN-RESISTANT Staphylococcus aureus-IVc CLONE RECEOVERED FROM HOSPITAL AND COMMUNITY SETTINGS OVER A 17-YEAR PERIOD FROM 12 COUNTRIES INVESTIGATED BY WHOLE-GENOME SEQUENCING
(2023)Background A novel Panton–Valentine leukocidin (PVL)-positive meticillin-resistant Staphylococcus aureus (MRSA) clonal complex (CC)5-MRSA-IVc (‘Sri Lankan’ clone) was recently described from Sri Lanka. Similar isolates ... -
Enhanced Typing and Tracking of Methicillin-Resistant Staphylococcus aureus and Methicillin-Susceptible S. aureus in Irish Hospitals using Whole-Genome Sequencing
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2019)Methicillin-resistant Staphylococcus aureus (MRSA) are a major cause of healthcare-associated and community-associated infection worldwide, with many clones having achieved pandemic status. The development of high-throughput ... -
An Investigation of the Prevalence, Population Structure and Relatedness of Environmental, Healthcare Worker and Patient Staphylococcus aureus Isolates Recovered from Multi-bed Patient Rooms in an Irish Teaching hospital by Whole-Genome Sequencing
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2020)The putative role of the air in Staphylococcus aureus transmission in multi-bed ward areas of hospitals, where the majority of in-patients are cared for, has not yet been elucidated. The work described in this thesis ... -
An investigation of the temporal dynamics of staphylococcus aureus nasal and oropharyngeal carriage amongst oral / dental healthcare workers
(Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2017)ABSTRACT Background: Approximately 30% of humans are Staphylococcus aureus nasal carriers and oro-nasal trafficking of the organisms is frequent. Carriage of S. aureus can be persistent or transient. Healthcare workers ... -
METICILLIN-RSISTANT Staphylococcus aureus TRANSMISSION AMONG HEALTHCARE WORKERS, PATIENTS AND THE ENVIRONMENT IN A LARGE ACUTE HOSPITAL UNDER NON-OUTBREAK CONDITIONS INVESTIGATED BY WHOLE-GENOME SEQUENCING
(2021)Background: The role of meticillin-resistant Staphylococcus aureus (MRSA) colonization of healthcare workers (HCWs), patients and the hospital environment in MRSA transmission in non-outbreak settings is poorly understood. Aims: ... -
A novel multidrug-resistant PVL-negative CC1-MRSA-1 IV clone emerging in Ireland and Germany likely originated in South-Eastern Europe
(2019)This study investigated the recent emergence of multidrug-resistant Panton-Valentine leukocidin (PVL)-negative CC1-MRSA-IV in Ireland and Germany. Ten CC1-MSSA and 139 CC1-MRSA isolates recovered in Ireland between 2004 ... -
PANTON-VALENTINE LEUKOCIDIN-POSITIVE STAPHYLOCOCCUS AUREUS IN IRELAND 2002-2011: TWENTY-ONE CLONES, FREQUENT IMPORTATION OF CLONES, TEMPORAL SHIFTS OF PREDOMINANT METHICILLIN-RESISTANT S. AUREUS AND INCREASING MULTIRESISTANCE
(2014)There has been a worldwide increase in community-associated (CA) methicillin-resistant Staphylococcus aureus (MRSA) infections. CA-MRSA isolates commonly produce the Panton-Valentine leukocidin toxin encoded by the pvl ... -
STAPHYLOCOCCAL CASSETTE CHROSOMOME MEC: RECENT ADVANCES AND NEW INSIGHTS
(2013)Staphylococcal cassette chromosome (SCC) elements are complex mobile genetic elements that often carry antimicrobial resistance and in some cases virulence-associated genes. In addition to SCCmec, which harbours the ...