Browsing by Subject "M.D. Trinity College Dublin"
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Acidosis at birth in term infants and early neurophysiological and cardiovascular changes
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2005)This thesis was mounted to evaluate and quantify the role of umbilical cord pH measurements in relation to the baby’s clinical condition, electroencephalographic pattern, heart rate variability and analysis of sucking ... -
Checking the weight of children in general practice
(Trinity College (Dublin, Ireland). Department of Public Health and Primary Care, 2015)Childhood overweight is a serious health concern. Checking the weight of the child can be done in the primary care setting, where GPs have the opportunity to check the weight of children attending for routine care.It is ... -
Children and adolescents with cystic fibrosis attending the three specialist Dublin respiratory units : clinical, metabolic, quality of life and genetic aspects
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Paediatrics, 2008)Patients with cystic fibrosis related diabetes (CFRD) have a six-fold increase in morbidity and mortality (Moran, 2002a). CFRD is usually asymptomatic and can remain undetected for up to four years prior to diagnosis. ... -
Defining inherited haematological disease within the Irish traveller population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2006)The Traveller Community in Ireland constitutes a minority of nomadic or semi-nomadic people, sharing a common Irish ancestry. The Traveller Health Study showed that in 1987, Travellers were only reaching the life expectancy ... -
Investigation of apraxia of speech and linguistic dysprosody following acute ischaemic hemispheral stroke
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Medical Gerontology, 2011)Apraxia of speech (AOS) is a disorder of motor speech programming. Affected patients typically have hesitant, groping speech with impaired prosody. Automatic speech is relatively well preserved compared to propositional ... -
Investigation of the link between obesity and breast cancer - the role of adipose tissue in the development and propagation of malignancy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2010)Obesity and the metabolic syndrome are emerging risk factors for breast cancer. They are associated with increased incidence, an increased recurrence rate and a poorer prognosis. Despite this epidemiological evidence to ... -
Left ventricular diastolic function in early hypertension
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Pharmacology & Therapeutics, 2008)This thesis presents the development of clinical applications of the relatively new ultrasound modality, TDI in conjunction with the earlier more established modalities of echocardiography. The contents of this thesis ... -
Mental disorders in the community dwelling elderly
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2000)The elderly population is increasing both in numbers and as a proportion of the overall population. Mental disorders are common among the elderly. Most older people with mental disorders live in the community and attend ... -
Minimal residual disease in cancer of the oesophagus and gastro-oesophageal junction
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2009)Epithelial tumours are the most common form of cancer and are responsible for the majority of cancer-related deaths in Western industrialized countries. Minimal residual disease following neo-adjuvant therapy or primary ... -
Obesity, insulin resistance and Type 2 Diabetes in young Irish people
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The epidemic of obesity in Irish youth, one of the highest ranking internationally, represents a major threat to public health. However, little is known of the metabolic and clinical characteristics of this cohort. I ... -
Predictors of response of rectal cancer to neoadjuvant radiochemotherapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2007)Rectal cancers staged as cT3/T4 +/- node positive routinely receive neoadjuvant radiochemotherapy (RCT) followed by total mesorectal excision (TME). By this approach tumours can be both downstaged and downsized resulting ... -
Prostate cancer progression to androgen independence - do changes in the androgen receptor CAG repeat number play a role?
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2007)Prostate cancer is the commonest non-cutaneous male malignancy and is the second commonest cause of cancer-related deaths in many Western countries. Approximately half of all men diagnosed with prostate cancer will have ... -
Sensory studies in adult-onset primary torsion dystonia
(Trinity College. Institute of Neuroscience, 2011)Dystonia is a disorder of movement characterized by prolonged muscle contractions, causing sustained twisting movements and abnormal postures of the affected body parts. Sensory symptoms including pain are frequently ... -
Sleeping with the head [up] of the bed tilted up: physiology & therapy
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)Orthostatic hypotension (OH) is common and affects people with increasing age and co-morbidity. It is associated with increased vascular risk, falls and dementia. While pharmacological and non-pharmacological treatments ... -
Subsyndromal depression and anxiety predictors, consequences and two year outcome in the Irish elderly
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Psychiatry, 2008)Depression is the commonest mental illness in late life and frequently occurs co- morbidly with anxiety. While all levels of illness severity have been reported a significant proportion of older adults suffer with clinically ... -
Systemic inflammation after cardiac surgery
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2008)Genetically determined inter-individual variation in cytokine production, influences outcome in patients with systemic inflammation and severe sepsis. However outcome in patients with sepsis is also dependant on the presence ... -
The effect of major surgery on systemic and splanchnic immune function : examining the two-hit and gut hypotheses of the systemic inflammatory response syndrome
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Surgery, 2006)The systemic inflammatory response syndrome (SIRS), sepsis and multiple organ dysfunction syndrome (MODS) are recognized sequelae of complex major surgery and underlie significant morbidity and mortality. The systemic ... -
The immune response to Hepatitis C host genetic factors influencing the out-come of Hepatitis C viral infection, in a cohort infected from a single source
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Clinical Medicine, 2008)The Immune response to Hepatitis C; Host genetic factors influencing the out-come of Hepatitis C viral infection, in a cohort infected from a single source. A coordinated response from both the innate and adaptive arms of ... -
The influence of inherited thrombophilia, endothelial activation and fibrinolysis on placental morphology and vasculature and on maternal and fetal outcome, in a low risk primigravid population
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Obstetrics and Gynaecology, 2009)A number of inherited thrombophilias have been associated with adverse events occurring during pregnancy. A common feature of these abnormalities is their ability to alter endothelial function and to increase thrombin ... -
The protein C pathway : linking inflammation and coagulation
(Trinity College (Dublin, Ireland). School of Medicine. Discipline of Haematology, 2000)Activated protein C (APC) is a natural anticoagulant and plays a pivotal role in coagulation homeostasis by inhibiting factors Villa and Va. Recent data suggests that APC also negatively regulates pro-inflammatory cytokine ...