Browsing by Subject "Hippocampus"
Now showing items 1-14 of 14
-
α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR.
(2015)The immunoregulatory function of single-Ig-interleukin-1 related receptor (SIGIRR) is derived from its ability to constrain the inflammatory consequences of interleukin (IL)-1R and toll-like receptor (TLR)4 activation. ... -
Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL
(2012)Altered synaptic morphology, progressive loss of synapses and glial (astrocyte and microglial) cell activation are considered as characteristic hallmarks of ageing. Recent evidence suggests that there is a concomitant ... -
Amyloid precursor protein knockdown by siRNA impairs spontaneous alternation in adult mice.
(2007)The cleavage-product of amyloid precursor protein (APP) constitutes the core component of plaques found in the brains of Alzheimer's disease (AD) patients. APP is ubiquitously expressed and its precise physiological functions ... -
Basal forebrain volume, but not hippocampal volume, is a predictor of global cognitive decline in patients with alzheimer's disease treated with cholinesterase inhibitors
(2018)Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes ... -
Changes in resting connectivity with age: A simultaneous electroencephalogram and functional magnetic resonance imaging investigation.
(2013)Resting fluctuations in the blood oxygenation level-dependent signal have attracted considerable interest for their sensitivity to pathological brain processes. However, these analyses are susceptible to confound by nonneural ... -
Early Hippocampal Synaptic Loss Precedes Neuronal Loss and Associates with Early Behavioural Deficits in Three Distinct Strains of Prion Disease
(2013)Prion diseases are fatal neurodegenerative diseases of the CNS that are associated with the accumulation of misfolded cellular prion protein. There are several different strains of prion disease defined by different patterns ... -
The effect of Medial Septum Stimulation on Hippocampal Electrophysiology and Behaviour of Freely Moving Rats
(Trinity College Dublin. School of Psychology. Discipline of Psychology, 2020)This study focuses on the interaction between the medial septum and hippocampus in freely moving animals. To investigate this circuit, we used electrophysiological techniques combined with behavioural tasks. The medial ... -
Effects of the neurogranin variant rs12807809 on thalamocortical morphology in schizophrenia.
(2013)Although the genome wide supported psychosis susceptibility neurogranin (NRGN) gene is expressed in human brains, it is unclear how it impacts brain morphology in schizophrenia. We investigated the influence of NRGN ... -
Extrafield activity shifts the place field center of mass to encode aversive experience
(2019)Hippocampal place cells are known to have a key role in encoding spatial information. Aversive stimuli, such aspredator odor, evoke place field remapping and a change in preferred firing locations. However, it remains ... -
Hippocampal inputs mediate theta-related plasticity in anterior thalamus
(Elsevier, 2011)Hippocampally-driven oscillatory activity at theta frequency is found in the diencephalon, but an understanding of the fundamental role of theta in the hippocampo-diencephalic circuit remains elusive. An important strategy ... -
A neural cell adhesion molecule-derived peptide, FGL, attenuates glial cell activation in the aged hippocampus
(Elsevier, 2011)Neuroglial activation is a typical hallmark of ageing within the hippocampus, and correlates with age-related cognitive deficits. We have used quantitative immunohistochemistry and morphometric analyses to investigate ... -
Regulation of synaptic strength & AMPA receptor subunit composition by PICK1
(2004)PICK1 (protein interacting with C kinase-1) regulates the surface expression of the AMPA receptor (AMPAR) GluR2 subunit, however,the functional consequences of this interaction are not well understood. Previous work has ... -
Suppressing the encoding of new information: A behavioral study derived from principles of hippocampal function.
(2013)Cognitive processes do not occur in isolation. Interactions between cognitive processes can be observed as a cost in performance following a switch between tasks, a cost that is greatest when the cognitive requirements ...