Browsing by Subject "Hepatitis C"
Now showing items 1-14 of 14
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CD4+ T-lymphocyte telomere length is related to fibrosis stage, clinical outcome and treatment response in chronic hepatitis C virus infection.
(Elsevier, 2010)BACKGROUND & AIMS: Increasing age is associated with impaired immune function and in chronic HCV infection specifically, with progressive fibrosis, liver failure, HCC and impaired responses to antiviral therapy. T-lymphocyte ... -
An Examination of Physical Activity, Cardiorespiratory Fitness and Cardio-metabolic Health through the Modern Hepatitis C Continuum
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2019)Hepatitis C (HCV) is an established global health issue with an approximated worldwide incidence of 3%. Hepatic features of chronic hepatitis C; such as hepatic fibrosis, steatosis and cirrhosis, and extrahepatic features ... -
Exercise Therapy as a Treatment for Chronic Liver Disease
(Trinity College Dublin. School of Medicine. Discipline of Physiotherapy, 2020)Hepatitis C (HCV) and Non-Alcoholic Fatty Liver Disease (NAFLD) are among the leading causes of chronic inflammatory liver disease. HCV and NAFLD present with numerous hepatic and extrahepatic features which culminates in ... -
Hepatitis C in the era of direct-acting antivirals: real-world costs of untreated chronic hepatitis C; a cross-sectional study.
(2015)ACKGROUND: Recent advances in Hepatitis C therapeutics offer the possibility of cure but will be expensive. The cost of treatment may be partially offset by the avoidance of advanced liver disease. We performed a ... -
Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses.
(2014)TNF-α is a proinflammatory cytokine, dramatically elevated during pathogenic infection and often responsible for inflammation-induced disease pathology. SOCS proteins are inhibitors of cytokine signaling and regulators of ... -
Hepatitis C virus targets the T cell secretory machinery as a mechanism of immune evasion.
(2011)T cell activation and the resultant production of interleukin (IL-2) is a central response of the adaptive immune system to pathogens, such as hepatitis C virus (HCV). HCV uses sev- eral mechanisms to evade both the ... -
Improvement in cognitive impairment following a 12-week aerobic exercise intervention in individuals with non-cirrhotic chronic hepatitis C
(2020)Cognitive impairment occurs in 30%-50% of patients with non-cirrhotic chronic hepatitis C virus (HCV) infection. Exercise is beneficial in preventing and treating cognitive impairment and cardiometabolic abnormalities in ... -
Innate immune genes synergize to predict increased risk of chronic disease in hepatitis C virus infection.
(2011)Hepatitis C is a common infection with significant morbidity and mortality, and only a minority of patients successfully clear the infection. Identification of factors that influence disease progression in HCV infection ... -
Molecular footprints reveal the impact of the protective HLA-A*03 allele in hepatitis C virus infection.
(2011)Background and aims: CD8 T cells are central to the control of hepatitis C virus (HCV) although the key features of a successful CD8 T cell response remain to be defined. In a cohort of Irish women infected by a single ... -
Novel Screening Strategies for HIV, Hepatitis B and C Infection
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Abstract Title: Novel Screening Strategies for HIV, Hepatitis B and C Infection. Author: Dr Sarah O?Connell Introduction: Despite prevention measures in place, rates of HIV infection have failed to decline in Ireland in ... -
A novel vaccine strategy employing serologically different chimpanzee adenoviral vectors for the prevention of HIV-1 and HCV coinfection
(2019)Background: Nearly 3 million people worldwide are coinfected with HIV and HCV. Affordable strategies for prevention are needed. We developed a novel vaccination regimen involving replication-defective and serologically ... -
The role of chemokines in acute and chronic hepatitis C infection.
(2014)Hepatitis C imposes a significant burden on global healthcare. Chronic infection is associated with progressive inflammation of the liver which typically manifests in cirrhosis, organ failure and cancer. By virtue of ... -
A study of the clinical impact and outcomes of pharmacist-led interventions in the outpatient model of care for Hepatitis C patients in Ireland and their development into a novel complex intervention toolkit
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2020)Given the high rates of sustained virological response and good tolerability of direct-acting antiviral regimens, international guidelines now recommend that all Hepatitis C infected patients be considered for access to ... -
Therapeutic outcomes, immunological responses to treatment and vaccine preventative strategies for Hepatitis C in HIV seropositive individuals
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2018)Introduction: HIV and Hepatitis C virus (HCV) represent significant causes of morbidity and mortality worldwide. Because of shared routes of transmission co-infection is common. Recent advances in treatment for both ...