Browsing by Subject "Gastroenterology"
Now showing items 1-8 of 8
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Abnormal Notochord Branching is Associated with Foregut Abnormalities in an Adriamycin Treated Mouse Model
(University of Edinburgh (datashare), 2011)Oesophageal atresia (OA) and tracheooesophageal fistula (TOF) are relatively common human congenital malformations of the foregut where the oesophagus does not connect with the stomach and there is an abnormal connection ... -
E-health empowers patients with ulcerative colitis: a randomised controlled trial of the web-guided 'Constant-care' approach.
(2010)Background: The natural history of ulcerative colitis requires continuous monitoring of medical treatment via frequent outpatient visits. The European health authorities' focus on e-health is increasing. Lack of easy access ... -
Golgi phosphoprotein 2 (GOLPH2) is a novel bile acid-responsive modulator of oesophageal cell migration and invasion
(2015)Background: The aetiology of Barrett’s oesophagus (BO) and oesophageal cancer is poorly understood. We previously demonstrated that Golgi structure and function is altered in oesophageal cancer cells. A Golgi-associated ... -
Helicobacter pylori increases proliferation of gastric epithelial cells
(BMJ, 1996)The direct and indirect effects of helicobacter pylori on cell kinetics of gastric epithelial cell line AGS were investigated by flow cytometric analysis of Ki-67 positive cells and by MTT assay. Flow cytometric analysis ... -
Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function
(2010)Background and Aims: HIF prolyl hydroxylase inhibitors are protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the therapeutic target(s) and mechanism(s) involved. Methods: The effect ... -
Lower gastrointestinal symptoms and symptoms-based triaging systems are poor predictors of clinical significant disease on colonoscopy.
(2020)Introduction: Lower gastrointestinal symptoms (LGS) are a common cause of referral to the gastroenterology service. International guidelines are available to prioritise referrals. Some studies have reported that symptoms ... -
Profiling Serum and Tissue Biomarkers of Vedolizumab Therapy Response in Inflammatory Bowel Disease.
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Introduction: Vedolizumab (VDZ) is a novel biologic agent proven effective for Inflammatory bowel disease (IBD), however, a significant proportion of patients do not respond to VZD treatment Aims: This thesis evaluates ... -
The Use of Proton Pump Inhibitors Among Older Adults with Intellectual Disability: A Cross Sectional Observational Study.
(2018)Background: Older people with Intellectual Disability (ID) have a high prevalence of gastrointestinal conditions such as Gastro-Oesophageal Reflux Disease (GORD). However, despite this, information about treatment, in ...