Browsing by Subject "Epilepsy"
Now showing items 1-20 of 21
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A 5-Year Audit of Paediatric Patients Presenting to an Emergency Department with Status Epilepsy Requiring Second-Line Medication
(2023)Aim: Audit management of children presenting to Paediatric Emergency Department (PED) who require second-line medication for seizure control. Method: Retrospective electronic chart review over a 5-year period (March ... -
Are we levelling the playing field? Exploring if reasonable accommodations provided for students with disabilities in higher education remove barriers and impact on the student experience
(Trinity College Dublin, 2017)This research thesis explores the experiences of students with disabilities in Trinity College Dublin (Trinity) and asks if the provision of reasonable accommodations remove barriers and impact on the student experience. ... -
Claudin-5 expression at the Blood Brain Barrier and its therapeutic potential in neurological disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Breakdown of the blood brain barrier's (BBB) integrity is a hallmark pathology in numerous neurological disorders. However, while research and therapeutic development has mostly focussed on neuronal function, the high ... -
Drug Burden Index to Define the Burden of Medicines in Older Adults with Intellectual Disabilities: An Observational Cross-Sectional Study
(2018)Aims: The drug burden index (DBI) is a dose‐related measure of anticholinergic and sedative drug exposure. This cross‐sectional study described DBI in older adults with intellectual disabilities (ID) and the most ... -
Epilepsy in Ireland: Towards the primary-tertiary care continuum
(2010)Background Epilepsy is a chronic neurological disease affecting people of every age, gender, race and socio-economic background. The diagnosis and optimal management relies on contribution from a number of healthcare ... -
Evidence‐based practice among epilepsy specialist nurses in the Republic of Ireland: Findings from the SENsE study
(2019)Aim: To describe how epilepsy specialist nurses in Ireland enact the evidence‐based practice dimension of their role. Background: The importance of epilepsy specialist nurses (ESNs) delivering evidence‐based care ... -
Genome-wide mega-analysis identifies 16 loci and highlights diverse biological mechanisms in the common epilepsies.
(2018)The epilepsies affect around 65 million people worldwide and have a substantial missing heritability component. We report a genome-wide mega-analysis involving 15,212 individuals with epilepsy and 29,677 controls, which ... -
Health-related quality of life in narcolepsy: A systematic review and meta-analysis
(2021)To date, there has been no systematic analysis of the literature regarding health-related quality of life in narcolepsy. This systematic review aimed to examine the impact of narcolepsy on health-related quality of life, ... -
Heritability of subcortical volumetric traits in mesial temporal lobe epilepsy.
(2013)OBJECTIVES: We aimed to 1) determine if subcortical volume deficits are common to mesial temporal lobe epilepsy (MTLE) patients and their unaffected siblings 2) assess the suitability of subcortical volumetric traits ... -
A Longitudinal Examination of the Physical Health and Ageing of Individuals with Down syndrome in Ireland
Background: Over the past three decades the life expectancy of people with Down syndrome (DS) has dramatically increased with improvements in health service delivery, better knowledge, health care and advocacy. With increased ... -
Patients with epilepsy care experiences: Comparison between services with and without an epilepsy specialist nurse.
(2018)The aim of this study was to determine whether there were differences in experiences of care, satisfaction with care and quality of life between those who were in receipt of care from a service with an epilepsy specialist ... -
Patterns of Medication Use Associated with Epilepsy and Comorbid Behavioural and Mental Disorders in Older People with Intellectual Disability
(Trinity College Dublin. School of Pharmacy & Pharma. Sciences. Discipline of Pharmacy, 2022)Background: There is increasing concern worldwide regarding the levels of use and suboptimal prescribing of psychotropic medication in people with intellectual disability. Antipsychotics, in particular are often prescribed ... -
Physical functioning limitations and physical activity of people experiencing homelessness: A scoping review,
(2020)Background: Adults who are experiencing homelessness suffer higher levels of premature mortality and age-related medical conditions compared to the general population, but little is known about physical factors that influence ... -
The relationship between antiepileptic drug load and challenging behaviors in older adults with intellectual disability and epilepsy
(2021)Antiepileptic drugs (AEDs) may affect mood and behavior in people with epilepsy and intellectual disability. A high AED load, derived from AED polytherapy and/or high doses of AEDs, has been suggested to be a risk factor ... -
Restricted participation: Drivers, experiences and implications of disability stigma in Ethiopia
(2023)Background: Community-based inclusive development (CBID) acknowledges society’s critical role in supporting the active participation of persons with disabilities. However, research on how this approach relates to the ... -
Rett syndrome in Ireland: a demographic study.
(2024)Background: Rett syndrome (RTT) is a rare neurodevelopmental condition associated with mutations in the gene coding for the methyl-CpG-binding protein 2 (MECP2). It is primarily observed in girls and affects individuals ... -
Seizures in HIV: The case for special consideration
(2018)Purpose: This study aimed to determine the rate, cause and management of seizures in the context of potential ART–ASD interactions in a cohort of HIV + individuals. Methods: Records of 604 HIV + patients were reviewed ... -
Structural brain abnormalities in the common epilepsies assessed in a worldwide ENIGMA study
(Oxford University Press, 2018)Progressive functional decline in the epilepsies is largely unexplained. We formed the ENIGMA-Epilepsy consortium to understand factors that influence brain measures in epilepsy, pooling data from 24 research centres in ...