Browsing by Subject "Delirium"
Now showing items 1-13 of 13
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Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium
(2020)Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood and cognition. In vulnerable individuals, acute illness can also ... -
Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice
(2021)Locus coeruleus (LC)-derived noradrenaline is important in cognition and decreases with age, but the impact of prior noradrenaline deficiency on vulnerability to inflammation-induced acute cognitive dysfunction is ... -
Acute systemic inflammation exacerbates neuroinflammation in Alzheimer's disease: IL-1?? drives amplified responses in primed astrocytes and neuronal network dysfunction
(2021)Neuroinflammation contributes to Alzheimer’s disease (AD) progression. Secondary inflammatory insults trigger delirium and can accelerate cognitive decline. Individual cellular contributors to this vulnerability require ... -
Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms
(2018)Systemic inflammation can impair cognition with relevance to dementia, delirium and post-operative cognitive dysfunction. Episodes of delirium also contribute to rates of long-term cognitive decline, implying that these ... -
Biomarkers of delirium risk in older adults: a systematic review and meta-analysis
(2023)Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into ... -
Delirium
(2020)Delirium, a syndrome characterized by an acute change in attention, awareness and cognition, is caused by a medical condition that cannot be better explained by a pre-existing neurocognitive disorder. Multiple predisposing ... -
Home FIRsT: interdisciplinary geriatric assessment and disposition outcomes in the Emergency Department
(2020)Background: Older people in the Emergency Department (ED) are clinically heterogenous and some presentations may be better suited to alternative out-of-hospital pathways. A new interdisciplinary comprehensive geriatric ... -
Interactions Between Systemic Inflammation, Frailty And Neuroinflammation In Ageing And Neurodegeneration
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)Compelling evidence continues to define the pivotal role which inflammation plays in the progression of neurodegenerative diseases and ageing. It has emerged that inflammation outside the brain significantly contributes ... -
International drive to illuminate delirium: A developing public health blueprint for action
(2020)Presently, there is a clear societal and demographic imperative to identify and deliver interventions that are effective in reducing dementia. With the high failure rate of compounds in clinical trials, and with ... -
Non-Steroidal Anti-Inflammatory Drugs and Cognitive Function: Are Prostaglandins at the Heart of Cognitive Impairment in Dementia and Delirium ?
(2012)Studies of non-steroidal anti-inflammatory drugs (NSAIDs) in rheumatoid arthritis imply that inflammation is important in the development of Alzheimer's disease (AD). However, these drugs have not alleviated the symptoms ... -
A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank
(2020)Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it is particularly common among older adults, and is closely linked with underlying neurocognitive disorders. Evidence is mounting ... -
Systemic inflammation induces acute working memory deficits in the primed brain; relevance for delirium
(2012)Delirium is an acute, severe neuropsychiatric syndrome, characterized by cognitive deficits, that is highly prevalent in aging and dementia and is frequently precipitated by peripheral infections. Delirium is poorly ... -
Worsening Cognitive Impairment and Neurodegenerative Pathology Progressively Increase Risk for Delirium.
(2015)Background Delirium is a profound neuropsychiatric disturbance precipitated by acute illness. Although dementia is the major risk factor this has typically been considered a binary quantity (i.e., cognitively impaired ...