Browsing by Subject "Colorectal cancer"
Now showing items 1-12 of 12
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Bile acids modulate the Golgi membrane fission process via a protein kinase Ceta and protein kinase D-dependent pathway in colonic epithelial cells.
(2010)Deoxycholic acid (DCA) is a secondary bile acid that modulates signalling pathways in epithelial cells. DCA has been implicated in pathogenesis of colon carcinoma, particularly by activation of the protein kinase C (PKC) ... -
Characterising the prognostic potential of HLA-DR during colorectal cancer development
(2020)HLA-DR, an MHC class II molecule that mediates antigen presentation, is a favourable prognostic indicator in colorectal cancer (CRC). However, the dynamics and location of HLA-DR expression during CRC development are ... -
Comment on 'Interventions to improve exercise behaviour in sedentary people living with and beyond cancer: a systematic review'
(2014)Background: To systematically review the effects of interventions to improve exercise behaviour in sedentary people living with and beyond cancer. Methods: Only randomised controlled trials (RCTs) that compared an exercise ... -
The cost of survival: an exploration of colorectal cancer survivors? experiences of pain
(2017)Background: The Institute of Medicine report ‘From Cancer Patient to Cancer Survivor’ has drawn widespread attention to the experiences of cancer survivors. Research examining the symptom experiences of survivors are ... -
Determinants of short- and long-term survival from colorectal cancer in very elderly patients
(2014)PURPOSE: Over 5100 colorectal cancers (CRCs) are diagnosed in the United Kingdom in 85years and older age group per year but little is known of cancer progression in this group. We assessed clinical, pathological and ... -
Identifying Associations Between Quality of Life Outcomes and Healthcare-Related Variables Among Colorectal Cancer Survivors: A Cross-Sectional Survey Study
(2019)Background: Follow-up care and surveillance are essential components of colorectal cancer survivorship. However, the relative contribution of healthcare experiences to quality of life in cancer survivorship is poorly ... -
Immunopathological features of early age cancer: microsatellite instability in colorectal cancer
(Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2023)Title: Immunopathological features of early age cancer: microsatellite instability in colorectal cancer Background and hypothesis Deciphering the interplay between tumour biology and the immune system may aid the design ... -
KH-Type Splicing Regulatory Protein Controls Colorectal Cancer Cell Growth and Modulates the Tumor Microenvironment
(2019)KH-type splicing regulatory protein (KHSRP) is a multifunctional nucleic acid binding protein implicated in key aspects of cancer cell biology: inflammation and cell-fate determination. However, the role KHSRP plays in ... -
?Protein kinase C beta II suppresses colorectal cancer by regulating IGF-1 mediated cell survival?.
(2016)Despite extensive efforts, cancer therapies directed at the Protein Kinase C (PKC) family of serine/threonine kinases have failed in clinical trials. These therapies have been directed at inhibiting PKC and have, in some ... -
SMAD7 variant rs4939827 is associated with colorectal cancer risk in Croatian population.
(2013)Background Twenty common genetic variants have been associated with risk of developing colorectal cancer (CRC) in genome wide association studies to date. Since large differences between populations exist, generalisability ... -
Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer
(2011)Inflammatory mediators in the tumour microenvironment promote tumour growth, vascular development and enable evasion of anti-tumour immune responses, by disabling infiltrating dendritic cells. However, the constituents ... -
Using resource modelling to inform decision making and service planning: The case of colorectal cancer screening in Ireland
(2013)Background Organised colorectal cancer screening is likely to be cost-effective, but cost-effectiveness results alone may not help policy makers to make decisions about programme feasibility or service providers to plan ...