Browsing by Subject "Click chemistry"
Now showing items 1-3 of 3
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Investigating the Impact of Conformational Molecular Engineering on the Crystal Packing of Cavity Forming Porphyrins
(2019)Herein we report the synthesis of 5,10,15,20-tetraaryl-(X)-substituted- 2,3,7,8,12,13,17,18-octaethylporphyrins (OETArXPs) and a structural investigation of their solid-state properties via small molecule X-ray diffraction. ... -
Novel Approaches to Probe the Activity of Deubiquitinating Enzymes
(Trinity College Dublin. School of Chemistry. Discipline of Chemistry, 2021)Ubiquitination is a highly conserved post-translational modification that regulates a multitude of critical cellular events. This process is orchestrated by a complex enzymatic network. Deubiquitinating enzymes (DUBs) ... -
Synthesis and Evaluation of 1,2,3-Triazole-Containing Vinyl and Allyl Sulfones as Anti-Trypanosomal Agents
(2017)An approach is described to access 1,2,3‐triazole‐derived peptidyl vinyl sulfones as Trypanosoma brucei brucei inhibitors by using click chemistry, starting from a common azide intermediate. Among the triazole analogues, ...