Browsing by Subject "Claudin-5"
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Claudin-5 expression at the Blood Brain Barrier and its therapeutic potential in neurological disease
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)Breakdown of the blood brain barrier's (BBB) integrity is a hallmark pathology in numerous neurological disorders. However, while research and therapeutic development has mostly focussed on neuronal function, the high ... -
Claudin-5: A Pharmacological Target to Modify the Permeability of the Blood-Brain Barrier
(2021)Claudin-5 is the dominant tight junction protein in brain endothelial cells and exclusively limits the paracellular permeability of molecules larger than 400Da across the blood–brain barrier (BBB). Its pathological impairment ... -
Claudin-5: Gatekeeper of neurological function
(2019)Tight junction proteins of the blood–brain barrier are vital for maintaining integrity of endothelial cells lining brain blood vessels. The presence of these protein complexes in the space between endothelial cells creates ... -
Investigating the Circadian Regulation of the Inner Blood Retinal Barrier in Early and Intermediate Age-Related Macular Degeneration
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2021)Age-related macular degeneration (AMD) is the leading cause of central visual impairment worldwide. It is a multifactorial condition leading to the painless, progressive loss of central vision. There are currently no ...