Browsing by Subject "Cartilage"
Now showing items 1-10 of 10
-
Composition-function relations of cartilaginous tissues engineered from chondrocytes and mesenchymal stem cells isolated from bone marrow and infrapatellar fat pad
(2011)The objective of this study was to determine the functional properties of cartilaginous tissues generated by porcine MSCs isolated from different tissue sources, and to compare these properties to those derived from ... -
Glyoxal cross-linking of solubilized extracellular matrix to produce highly porous, elastic, and chondro-permissive scaffolds for orthopedic tissue engineering
(2019)Extracellular matrix (ECM)-derived implants hold great promise for tissue repair, but new strategies are required to produce efficiently decellularized scaffolds with the necessary porosity and mechanical properties to ... -
The identification of articular cartilage and growth plate extracellular matrix-specific proteins supportive of either osteogenesis or stable chondrogenesis of stem cells
(2020)Tissue-specific extracellular matrix (ECM) proteins can play a key role in regulating the fate of stem cells and can potentially be utilized for therapeutic applications. Realising this potential requires further ... -
In vitro assessment of primary human chondrocyte viability following treatment with intra-articular contrast agents and local anaesthetic
(Trinity College Dublin. School of Medicine. Discipline of Surgery, 2021)Title In vitro assessment of primary human chondrocyte viability following treatment with intra-articular contrast agents and local anaesthetic. Introduction Magnetic resonance (MR) and computed tomography (CT) direct ... -
Joint development recovery on resumption of embryonic movement following paralysis
(2021)Fetal activity in utero is a normal part of pregnancy and reduced or absent movement can lead to long-term skeletal defects, such as Fetal Akinesia Deformation Sequence, joint dysplasia and arthrogryposis. A variety of ... -
Mechanoregulatory role of TRPV4 in prenatal skeletal development
(2023)Biophysical cues are essential for guiding skeletal development, but the mechanisms underlying the mechanical regulation of cartilage and bone formation are unknown. TRPV4 is a mechanically sensitive ion channel involved ... -
Methacrylated Cartilage ECM-Based Hydrogels as Injectables and Bioinks for Cartilage Tissue Engineering
(2022)Articular cartilage (AC) possesses a limited healing potential, meaning that untreated focal joint defects typically progress, leading to the development of degenerative diseases such as osteoarthritis. Several clinical ... -
Quantifying the tolerance of chick hip joint development to temporary paralysis and the potential for recovery
(2021)Background: Abnormal fetal movements are implicated in joint pathologies such as arthrogryposis and developmental dysplasia of the hip (DDH). Experimentally induced paralysis disrupts joint cavitation and morphogenesis ...