Browsing by Subject "CANCER"
Now showing items 1-20 of 37
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Acidosis significantly alters immune checkpoint expression profiles of T cells from oesophageal adenocarcinoma patients
(2023)Tumour acidosis contributes to cancer progression by inhibiting anti-tumour immunity. However, the effect of acidosis on anti-tumour T cell phenotypes in oesophageal adenocarcinoma (OAC) is unknown. Therefore, this study ... -
Aspirin and P2Y<inf>12</inf> inhibition attenuate platelet-induced ovarian cancer cell invasion
(2015)Background: Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian ... -
Chemokine-targeted therapies: An opportunity to remodel immune profiles in gastro-oesophageal tumours
(2021)Immunotherapies are transforming outcomes for many cancer patients and are quickly becoming the fourth pillar of cancer therapy. However, their efficacy of only ∼25% in gastro-oesophageal cancer has been disappointing. ... -
Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells
(2020)Magnetic hyperthermia involves the use of iron oxide nanoparticles to generate heat in tumours following stimulation with alternating magnetic fields. In recent times, this treatment has undergone numerous clinical trials ... -
The cost of survival: an exploration of colorectal cancer survivors? experiences of pain
(2017)Background: The Institute of Medicine report ‘From Cancer Patient to Cancer Survivor’ has drawn widespread attention to the experiences of cancer survivors. Research examining the symptom experiences of survivors are ... -
Evaluation of the effect of solid and cationic lipids on siRNA delivery systems
(2020)This study aims to develop nanoparticles with different types of solid and cationic lipids and evaluate them as siRNA delivery systems. For this purpose, we prepared a series of lipid nanoparticles by combining cationic ... -
Evidence for the Need to Evaluate More Than One Source of Extracellular Vesicles, Rather Than Single or Pooled Samples Only, When Comparing Extracellular Vesicles Separation Methods
(2021)To study and exploit extracellular vesicles (EVs) for clinical benefit as biomarkers, therapeutics, or drug delivery vehicles in diseases such as cancer, typically we need to separate them from the biofluid into which they ... -
Extracellular vesicles in blood: are they viable as diagnostic and predictive tools in breast cancer?
(2020)Extracellular vesicles (EVs), often described as mini-maps of their cells of origin, are found in the bloodstream and can be rich sources of cargo released from cancer cells. As such, they could be collected through minimally ... -
Factors influencing adherence to a calorie posting policy in Irish public hospitals. SPHeRE Policy Brief
(SPHeRE, 2022)Evidence shows calorie posting has positive effects on consumer food choice and industry/catering practices; however, few studies report the extent to which calorie posting is implemented as designed. The current study ... -
Fractalkine Elicits Chemotactic, Phenotypic, and Functional Effects on CX3CR1+ CD272 NK Cells in Obesity-Associated Cancer
(2021)Esophagogastric adenocarcinomas (EAC) are obesity-associated malignancies underpinned by severe immune dysregulation and inflammation. Our previous work indicates that NK cells migrate to EAC omentum, where they undergo ... -
The future of Extracellular Vesicles as Theranostics - an ISEV meeting report
(2020)The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs in ... -
Gene Expression Profiling
(Humana Press, 2009) -
Identifying Associations Between Quality of Life Outcomes and Healthcare-Related Variables Among Colorectal Cancer Survivors: A Cross-Sectional Survey Study
(2019)Background: Follow-up care and surveillance are essential components of colorectal cancer survivorship. However, the relative contribution of healthcare experiences to quality of life in cancer survivorship is poorly ... -
The impact of Esophageal Oncological Surgery on perioperative immune function; implications for adjuvant immune checkpoint inhibition
(2022)Background: Immune checkpoint inhibitors (ICIs) are being investigated for their role as an adjunct in the multimodal treatment of esophageal adenocarcinoma (EAC). The most effective time to incorporate ICIs remains ...