Browsing by Subject "Biomarkers"
Now showing items 1-19 of 19
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Biomarker Signatures of Two Phenotypical Pre-Frailty Types in The Irish Longitudinal Study on Ageing
(2022)Abstract: We investigated the biomarker signatures of two previously reported phenotypical prefrailty (PF) types in the first wave of The Irish Longitudinal Study on Ageing (TILDA): PF1 (unexplained weight loss and/or ... -
Biomarkers of delirium risk in older adults: a systematic review and meta-analysis
(2023)Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into ... -
Brain-predicted age difference score is related to specific cognitive functions: a multi-site replication analysis
(2020)Brain-predicted age difference scores are calculated by subtracting chronological age from ‘brain’ age, which is estimated using neuroimaging data. Positive scores reflect accelerated ageing and are associated with increased ... -
Characterisation of innate immune responses in children with Down syndrome
(Trinity College Dublin. School of Medicine. Discipline of Paediatrics, 2020)Introduction: Down syndrome (DS) is associated with increased incidence of infections in childhood, higher mortality from sepsis, and other inflammatory conditions such as arthropathy, thyroid and coeliac disease. Several ... -
Circulating micronutrient biomarkers are associated with three measures of frailty: Evidence from The Irish Longitudinal Study on Ageing (TILDA).
(2019)Objectives: To examine the associations between 3 frailty instruments and circulating micronutrients in a large representative sample of older adults. Design: Cross-sectional data from a nationally representative cohort ... -
The Clinical Applications of Tissue Biomarkers in Prostate Cancer
(2020)The clinical course of localized prostate cancer varies widely, from indolent disease unlikely to need treatment to aggressive disease requiring intensive, multimodal therapy. Traditionally, treatment decisions have been ... -
Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction
(2012)We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia, by gene-level integration of genome-wide association study data with other genetic and ... -
Effect of immunology biomarkers associated with hip fracture and fracture risk in older adults
(2023)Osteoporosis is a skeletal disease that can increase the risk of fractures, leading to adverse health and socioeconomic consequences. However, current clinical methods have limitations in accurately estimating fracture ... -
Investigating the Potential and Pitfalls of EV-Encapsulated MicroRNAs as Circulating Biomarkers of Breast Cancer
(2020)Extracellular vesicles (EVs) shuttle microRNA (miRNA) throughout the circulation and are believed to represent a fingerprint of the releasing cell. We isolated and characterized serum EVs of breast tumour-bearing animals, ... -
NANOTECHNOLOGICAL CANTILEVER-BASED ANALYSIS OF INFECTIOUS DISEASE BIOMARKERS
(Trinity College Dublin. School of Physics. Discipline of Physics, 2022)Our history is pin-pointed with several events when a viral, parasite or bacterial pathogen disrupted its boundaries and influenced human culture and behaviour, shaping human past and present times. The continuous appearance ... -
Prognostication in advanced cancer by combining actigraphy-derived rest-activity and sleep parameters with routine clinical data: an exploratory machine learning study
(2023)Survival prediction is integral to oncology and palliative care, yet robust prognostic models remain elusive. We assessed the feasibility of combining actigraphy, sleep diary data, and routine clinical parameters to ... -
Prospective Study of a Novel Diagnostic Algorithm for Investigating and Managing Gastrointestinal Disease Through The Appropriate Use of Biomarkers and Wireless Based Capsule Endoscopy
This chapter gives a general outline of the thesis for better understanding of issues surrounding research areas and studies that have been performed. Lower Gastrointestinal (GI) Symptoms are common and often warrant further ... -
A roadmap to advance delirium research: Recommendations from the NIDUS Scientific Think Tank
(2020)Delirium is an acute disorder of attention and cognition. It occurs across the life span, yet it is particularly common among older adults, and is closely linked with underlying neurocognitive disorders. Evidence is mounting ... -
Sestrin-2 is significantly increased in malignant pleural effusions due to lung cancer and is potentially secreted by pleural mesothelial cells.
(2016)Objectives: Sestrin-2 (Sesn2) belongs to a family of highly conserved antioxidant proteins that were discovered as p53-inducible proteins and inhibits cell growth and proliferation. Our aim was to assess the levels of Sesn2 ... -
Systemic gene dysregulation in classical Galactosaemia: Is there a central mechanism?
(2014)Classical Galactosaemia is a rare disorder of carbohydrate metabolism caused by a deficiency of galactose-1-phosphate uridyltransferase (GALT). The disease is life-threatening in the neonate, and the only treatment option ... -
Voluntary fortification is ineffective to maintain the vitamin B12 and folate status of older Irish adults: evidence from the Irish Longitudinal Study on Ageing (TILDA).
(2018)Mandatory fortification of staple grains with folic acid and/or vitamin B12 (B12) is under debate in many countries including Ireland, which has a liberal, but voluntary, fortification policy. Older adults can be at risk ...