Browsing by Subject "Alzheimer's disease (AD)"
Now showing items 1-9 of 9
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Altered Brain Activation During a Verbal Working Memory Task in Subjects with Amnestic Mild Cognitive Impairment.
(2010)In subjects with Mild Cognitive Impairment (MCI) memory disorders indicate a high risk for conversion to Alzheimer?s disease (AD). The objective of this study was to delineate the differences in brain activation between ... -
Basal forebrain volume, but not hippocampal volume, is a predictor of global cognitive decline in patients with alzheimer's disease treated with cholinesterase inhibitors
(2018)Background: Predicting the progression of cognitive decline in Alzheimer's disease (AD) is important for treatment selection and patient counseling. Structural MRI markers such as hippocampus or basal forebrain volumes ... -
Everyday episodic memory in amnestic mild cognitive impairment: a preliminary investigation
(2011)Background: Decline in episodic memory is one of the hallmark features of Alzheimer's disease (AD) and is also a defining feature of amnestic Mild Cognitive Impairment (MCI), which is posited as a potential prodrome of ... -
Impaired posterior cingulate cortex?parahippocampus connectivity is associated with episodic memory retrieval problems in amnestic mild cognitive impairment
(2021)Episodic memory retention and retrieval decline are the most common impairments observed in amnestic mild cognitive impairment (aMCI) patients who progress to Alzheimer's disease (AD). Clinical electroencephalography ... -
Interaction between prion protein and toxic amyloid ß assemblies can be therapeutically targeted at multiple sites.
(2011)A role for PrP in the toxic effect of oligomeric forms of A?, implicated in Alzheimer's disease (AD), has been suggested but remains controversial. Here we show that PrP is required for the plasticity-impairing effects of ... -
Multiple Indices of Diffusion Identifies White Matter Damage in Mild Cognitive Impairment and Alzheimer s Disease
(PLoS, 2011)The study of multiple indices of diffusion, including axial (DA), radial (DR) and mean diffusion (MD), as well as fractional anisotropy (FA), enables WM damage in Alzheimer's disease (AD) to be assessed in detail. Here, ... -
Recent developments of functional magnetic resonance imaging research for drug development in Alzheimer's disease
(2011)The objective of this review is to evaluate recent advances in functional magnetic resonance imaging (fMRI) research in Alzheimer's disease for the development of therapeutic agents. The basic building block underpinning ... -
The Role of Variation at AßPP, PSEN1, PSEN2, and MAPT in Late Onset Alzheimer's Disease.
(2011)Rare mutations in A?PP, PSEN1, and PSEN2 cause uncommon early onset forms of Alzheimer's disease (AD), and common variants in MAPT are associated with risk of other neurodegenerative disorders. We sought to establish whether ... -
Soluble beta amyloid evokes alteration in brain norepinephrine levels: Role of nitric oxide and interleukin-1
(2015)Strong evidence showed neurotoxic properties of beta amyloid (Aβ) and its pivotal role in the Alzheimer's disease (AD) pathogenesis. Beside, experimental data suggest that Aβ may have physiological roles considering that ...