Browsing by Subject "ALS"
Now showing items 1-13 of 13
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The BCH message banking process, voice banking, and double dipping
(2021)Significant advances have been made in interventions to maintain communication and personhood for individuals with neurodegenerative conditions. One innovation is Message Banking, a clinical approach first developed at ... -
Detection of pleiotropic repeat expansions and their oligogenic contribution to amyotrophic lateral sclerosis
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)This thesis aims to advance our understanding of the genetic mechanisms that contribute to amyotrophic lateral sclerosis (ALS). The focus is on investigating pleiotropy in genetic contributors to ALS by examining the ... -
An Exploratory Spatial Analysis of ALS Incidence in Ireland over 17.5 Years (1995 - July 2013)
(2014)Abstract Introduction There has been much interest in spatial analysis of ALS to identify potential environmental or genetically caused clusters of disease. Results to date have been inconclusive. The Irish ALS register ... -
Measurement of Social Cognition in Amyotrophic Lateral Sclerosis: A Population Based Study
(2016)Background: Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease. Executive dysfunction is common in patients with ALS, with up to 50% of patients performing within an impaired range. ... -
Network Analysis in Motor Neuron Diseases: A Cortico-Muscular Coherence Study
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2022)Neurodegenerative conditions are associated with widespread changes in the motor networks. There is preliminary evidence from (f)MRI studies that the structural changes extend beyond the primary motor areas in cortical ... -
On the Use of Machine Learning in Genomic Prediction
(Trinity College Dublin. School of Genetics & Microbiology. Discipline of Genetics, 2023)This thesis explores the use of machine learning in the context of genomic prediction and the issue of confounding in such approaches. Traditionally, genomic prediction methods have made use of linear models with much ... -
Resting-state electroencephalographic biomarkers for tracking cognitive network dysfunction in amyotrophiclateral sclerosis
(Trinity College Dublin. School of Medicine. Discipline of Clinical Medicine, 2024)Amyotrophic lateral sclerosis (ALS) stands as a multifaceted neurological disorder that primarily affects both upper and lower motor neurons. However, research in neuroimaging, neuropsychology and neurobiology has shown ... -
Spinal cord markers in ALS - diagnostic and biomarker considerations
(2012)Background: Despite considerable involvement of the spinal cord in Amyotrophic Lateral Sclerosis (ALS), current biomarker research is primarily centred on brain imaging and CSF proteomics. In clinical practice, spinal ... -
Survival Analysis of Irish Amyotrophic Lateral Sclerosis Patients Diagnosed from 1995 2010
(2013)Introduction: The Irish ALS register is a valuable resource for examining survival factors in Irish ALS patients. Cox regression has become the default tool for survival analysis, but recently new classes of flexible ...