Browsing by Sponsor "National Institutes of Health (NIH)"
Now showing items 1-20 of 48
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Acute Inflammation Alters Brain Energy Metabolism in Mice and Humans: Role in Suppressed Spontaneous Activity, Impaired Cognition, and Delirium
(2020)Systemic infection triggers a spectrum of metabolic and behavioral changes, collectively termed sickness behavior, which while adaptive, can affect mood and cognition. In vulnerable individuals, acute illness can also ... -
The Adam family metalloprotease Kuzbanian regulates the cleavage of the roundabout receptor to control axon repulsion at the midline.
(2010)Slits and their Roundabout (Robo) receptors mediate repulsive axon guidance at the Drosophila ventral midline and in the vertebrate spinal cord. Slit is cleaved to produce fragments with distinct signaling properties. In ... -
Altered ribostasis: RNA-protein granules in degenerative disorders
(2013)The molecular processes that contribute to degenerative diseases are not well understood. Recent observations suggest that some degenerative diseases are promoted by the accumulation of nuclear or cytoplasmic RNA-protein ... -
Androgen receptor signaling in prostate cancer development and progression
(Carcinogenesis Press, 2011)The androgen receptor (AR) signaling axis plays a critical role in the development, function and homeostasis of the prostate. The classical action of AR is to regulate gene transcriptional processes via AR nuclear ... -
Attentional capture by emotional stimuli is preserved in patients with amygdala lesions
(Elsevier, 2011)The importance of cues signaling reward, threat or danger would suggest that they receive processing privileges in the neural systems underlying perception and attention. Previous research has documented enhanced processing ... -
B-Raf(V600E) and thrombospondin-1 promote thyroid cancer progression.
(2010)Although B-Raf(V600E) is the most common somatic mutation in papillary thyroid carcinoma (PTC), how it induces tumor aggressiveness is not fully understood. Using gene set enrichment analysis and in vitro and in vivo ... -
Common variants near ATM are associated with glycemic response to metformin in type 2 diabetes
(2011)Metformin is the most commonly used pharmacological therapy for type 2 diabetes. We carried out a GWA study on glycaemic response to metformin in 1024 Scottish patients with type 2 diabetes. Replication was in two cohorts ... -
Comprehensive characterization of cytochrome P450 isozyme selectivity across chemical libraries.
(Nature Publishing Group, 2009)The cytochrome P450 (CYP) gene family catalyzes drug metabolism and bioactivation and is therefore relevant to drug development. We determined potency values for 17,143 compounds against five recombinant CYP isozymes (1A2, ... -
Crystal structure of the integral membrane diacylglycerol kinase
(2013)Diacylglycerol kinase catalyses the ATP-dependent phosphorylation of diacylglycerol to phosphatidic acid for use in shuttling water-soluble components to membrane-derived oligosaccharide and lipopolysaccharide in the cell ... -
Crystal structure of the Toll/interleukin-1 receptor domain of human IL-1RAPL
(The American Society for Biochemistry and Molecular Biology, 2004)The Toll/interleukin-1 receptor (TIR) domain is conserved in the intracellular regions of Toll-like receptors (TLRs) and interleukin-1 receptors (IL-1Rs) as well as in several cytoplasmic adapter molecules. This domain has ... -
Crystallizing membrane proteins using lipidic mesophases.
(2009)A detailed protocol for crystallizing membrane proteins that makes use of lipidic mesophases is described. This has variously been referred to as the lipid cubic phase or in meso method. The method has been shown to be ... -
Crystallizing Transmembrane Peptides in Lipidic Mesophases
(2010)Structure determination of membrane proteins by crystallographic means has been facilitated by crystallization in lipidic mesophases. It has been suggested, however, that this so-called in meso method, as originally ... -
Developing pedigree-based strategies to analyse whole genome sequencing data for complex disorders: learning from schizophrenia
(Trinity College Dublin. School of Medicine. Discipline of Psychiatry, 2023)Complex genetic disorders are impacted by a range of DNA variation. Next generation sequencing (NGS) allows for the direct examination of this variation, but large sample numbers are required to identify rare variants in ... -
Direct correlation of structure changes and thermal events in hydrated lipid established by simultaneous calorimetry and time-resolved x-ray diffraction.
(1992)In many lipid systems, polymorphic and mesomorphic behavior depends on sample thermal history. To establish unequivocally the structural origin of endothermic and exothermic events in such systems, we have performed ... -
Do high blood folate concentrations exacerbate metabolic abnormalities in people with low vitamin B-12 status?
(2011)ABSTRACT Background: In elderly individuals with low serum vitamin B-12, those who have high serum folate have been reported to have greater abnormalities in the following biomarkers for vitamin B-12 defi- ciency: low ... -
Endothelial NOS, estrogen receptor beta, and HIFs cooperate in the activation of a prognostic transcriptional pattern in aggressive human prostate cancer.
(2009)The identification of biomarkers that distinguish between aggressive and indolent forms of prostate cancer (PCa) is crucial for diagnosis and treatment. In this study, we used cultured cells derived from prostate tissue ... -
Experience-dependent plasticity in visual cortex: Dendritic spines and visual responsiveness.
(2011)To determine the relationship between synaptic structural changes and cortical function, we recently published a study where we imaged dendritic spines using two-photon in vivo microscopy while monitoring network activity ... -
A fast, simple and robust protocol for growing crystals in the lipidic cubic phase
(2012)A simple and inexpensive protocol for producing crystals in the sticky and viscous mesophase used for membrane protein crystallization by the in meso method is described. It provides crystals that appear within 15–30 min ... -
Fear-enhanced visual search persists after amygdala lesions
(Elsevier, 2010)Previous research has indicated that the amygdala is a critical neural substrate of the emotional modulation of attention. However, a recent case-study suggests that the amygdala may not be essential for all types of ...