Browsing by Author "VOLKOV, YURI"
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Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity
DAVIES, ANTHONY; VOLKOV, YURI; WILLIAMS, YVONNE; PRINA MELLO, ADRIELE; KELLEHER, DERMOT P (2011)Background: Nanomaterials such as SiO2 nanoparticles (SiO2NP) are finding increasing applications in the biomedical and biotechnological fields such as disease diagnostics, imaging, drug delivery, food, cosmetics and ... -
Analysis of dynamic tyrosine phosphoproteome in LFA-1 triggered migrating T-cells.
LONG, AIDEEN; KELLEHER, DERMOT; DEMPSEY, EUGENE; VOLKOV, YURI; FREELEY, MICHAEL; VERMA, NAVIN (2011)The ordered, directional migration of T-lymphocytes is a key process during immune surveillance and response. This requires cell adhesion to the high endothelial venules or to the extracellular matrix by a series of surface ... -
CD44 cross-linking induces protein kinase C-regulated migration of human T lymphocytes
VOLKOV, YURI; KELLEHER, DERMOT P (2005) -
CdTe quantum dots induce activation of human platelets: Implications for nanoparticle hemocompatibility
PRINA MELLO, ADRIELE; SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS; VOLKOV, YURI (2015) -
CdTe quantum dots induce activation of human platelets: implications for particle hemocompatibility.
RADOMSKI, MAREK; VOLKOV, YURI; RADOMSKI, MAREK; VOLKOV, YURI (2015)New nanomaterials intended for systemic administration have raised concerns regarding their biocompatibility and hemocompatibility. Quantum dots (QD) nanoparticles have been used for diagnostics, and recent work suggests ... -
Characterization of interaction of magnetic nanoparticles with breast cancer cells
VOLKOV, YURI (2015)Background Different superparamagnetic iron oxide nanoparticles have been tested for their potential use in cancer treatment, as they enter into cells with high effectiveness, do not induce cytotoxicity, and are retained ... -
A comparison of catabolic pathways induced in primary macrophages by pristine single walled carbon nanotubes and pristine graphene
COLEMAN, JONATHAN; NICOLOSI, VALERIA; VOLKOV, YURI; O'NEILL, LUKE; MCGOVERN, IGNATIUS; NERL, HANNAH; DUESBERG, GEORG; MCEVOY, NIALL (2016)Understanding the correlation between the physico-chemical properties of carbonaceous nanomaterials and how these properties impact on cells and subcellular mechanisms is critical to their risk assessment and safe translation ... -
Cutting edge: protein kinase C beta expression is critical for export of Il-2 from T cells
VOLKOV, YURI; KELLEHER, DERMOT P; LONG, AIDEEN (2001) -
Detection of ErbB2: Nanotechnological solutions for clinical diagnostics
RAKOVICH, TATSIANA; PRINA MELLO, ADRIELE; MOVIA, DANIA; VOLKOV, YURI (2014) -
Determination of spiropyran cytotoxicity by high content screening and analysis for safe application in bionanosensing
GIORDANI, SILVIA; MOVIA, DANIA; VOLKOV, YURI; PRINA MELLO, ADRIELE (2010)The in vitro toxic response of spiropyrans in cellular models has not been previously addressed, despite the fact that such photoswitchable molecules have shown great potential as versatile and tunable components for ... -
Efficient treatment of breast cancer xenografts with multifunctionalized iron oxide nanoparticles combining magnetic hyperthermia and anti-cancer drug delivery
VOLKOV, YURI (2015)Introduction Tumor cells can effectively be killed by heat, e.g. by using magnetic hyperthermia. The main challenge in the field, however, is the generation of therapeutic temperatures selectively in the whole tumor ... -
Inside the crawling T cell: leukocyte function-associated antigen-1 cross-linking is associated with microtubule-directed translocation of protein kinase C isoenzymes beta(I) and delta
VOLKOV, YURI (1998)T cells activated via integrin receptors can polarize and start crawling locomotion with repeated cycles of cytoskeletal reassembly processes, many of which depend on phosphorylation. We demonstrate that protein kinase C ... -
Multifactorial determinants that govern nanoparticle uptake by human endothelial cells under flow.
GOUNKO, IOURI; PRINA MELLO, ADRIELE; VOLKOV, YURI (2012) -
Nanotechnologies for the study of the central nervous system
PRINA MELLO, ADRIELE; VOLKOV, YURI; CORVIN, AIDEN; TROPEA, DANIELA (2014)Description of novel nanotechnologies to deliver a translational bridge between basic and clinical neuroscience research. • Evaluation of novel in vitro and in vivo nanodiagnostic tools for neuroimaging and the ... -
Porphyrin-magnetite nanoconjugates for biological imaging
GOUNKO, IOURI; VOLKOV, YURI (2011)Background: The use of silica coated magnetic nanoparticles as contrast agents has resulted in the production of highly stable, non-toxic solutions that can be manipulated via an external magnetic field. As a result, the ... -
Protein kinase C isotypes theta, delta and eta in human lymphocytes: differential responses to signalling through the T-cell receptor and phorbol esters
VOLKOV, YURI (1997)The repertoire of novel and atypical protein kinase C (PKC) isotypes present in human T cells and their subcellular localization have not been fully characterized. We detected calcium-independent PKC activity in whole cell ... -
Quantum dots in nanomedicine: Recent trends, advances and unresolved issues
VOLKOV, YURI (2015)The review addresses the current state of progress in the use of ultra-small nanoparticles from the category of quantum dots (QDs), which presently embraces a widening range of nanomaterials of different nature, including ... -
The scaffolding protein CG-NAP/AKAP450 is a critical integrating component of the LFA-1-induced signaling complex in migratory T cells
KELLEHER, DERMOT P; VOLKOV, YURI (2006)