Browsing by Author "Tajber, Lidia"
Now showing items 1-20 of 44
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Anticrystal Engineering of Ketoprofen and Ester Local Anesthetics: Ionic Liquids or Deep Eutectic Mixtures?
Tajber, Lidia; Umerska, Anita; Bialek, Klaudia; Zotova, Julija; Skotnicki, Marcin (2020)Ionic liquids (ILs) and deep eutectic mixtures (DEMs) are potential solutions to the problems of low solubility, polymorphism, and low bioavailability of drugs. The aim of this work was to develop and investigate ketoprofen ... -
Carbohydrate-based Trojan microparticles as carriers for pulmonary delivery of lipid nanocapsules using dry powder inhalation
Tajber, Lidia (2020)This study proposes lipid nanocapsules (LNCs)-based Trojan particles made by entrapping 59 ± 3 nm LNCs in carbohydrate-based microparticles via spray drying. This work focused on optimisation of maintenance of the nanocarrier ... -
Characterisation and fundamental insight into the formation of new solid state, multicomponent systems of propranolol.
Tajber, Lidia (2021)The physiochemical properties of acidic or basic active pharmaceutical ingredients (APIs) can be optimised by forming salts with different counterions. The aim of this work was to synthesise a novel salt of propranolol ... -
Comparison of particle size methodology and assessment of nanoparticle tracking analysis (NTA) as a tool for live monitoring of crystallisation pathways
Tajber, Lidia; McComiskey, Kate P.M. (2018)Sample complexity and polydispersity presents challenges surrounding particle size measurements for nanoparticles (NPs). To ensure the delivery of high quality products to the marketplace it is imperative that this task ... -
Crystallo-co-spray drying as a new approach to manufacturing of drug/excipient agglomerates: impact of processing on the properties of paracetamol and lactose mixtures.
Tajber, Lidia (2020)The novel process of crystallo-co-spray drying of paracetamol and α-lactose monohydrate was investigated by varying the spray dryer inlet temperature and inlet feed solvent composition. A crystalline agglomerate was obtained ... -
Density Scaling in Ionic Glass-Former Controlled by Grotthuss Conduction
Tajber, Lidia; Wojnarowska, Z.; Paluch, M. (2019)We present investigations of the charge transport in an ionic glass-former carvedilol dihydrogen phosphate (CP) at various T–P–V thermodynamic conditions in terms of density scaling concept. The studied material was found ... -
Development and characterisation of soluble polymeric particles for pulmonary peptide delivery
Healy, Anne-Marie; Ehrhardt, Carsten; Corrigan, Owen; Tajber, Lidia (2010)Pulmonary administration of protein and peptide drugs using inhaled dry powder particles is an interesting alternative to parenteral delivery. The stabilisation of these molecules is essential to the maintenance of biological ... -
Development of salmon calcitonin (sCT) nanoporous / nanoparticulate microparticles for pulmonary delivery
Amaro, Maria Inês (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis focus on the development and production by spray drying of porous microparticulate systems designed for the pulmonary delivery of a therapeutic peptide - salmon calcitonin. The nanoporous/nanoparticulate ... -
The effect of electrostatic interactions on the formation of pharmaceutical eutectics
Tajber, Lidia (2018)Over the past decade, the formation of pharmaceutical eutectics has become a very attractive strategy to increase the bioavailability of active pharmaceutical ingredients (APIs). A great advantage of a eutectic phase, which ... -
Effect of electrostatic interactions on the relaxation dynamics of pharmaceutical eutectics
Tajber, Lidia (2019)In this paper, we investigate the temperature-dependent relaxation dynamics in the glassy and supercooled liquid state of dipolar and ionic eutectic mixtures made of two anesthetic agents (lidocaine and prilocaine) and ... -
Engineering a novel insulin delivery system
Dul, Maria (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis investigated the preparation of a novel system that would be suitable for the oral delivery of insulin. The genetic modification of insulin gene to establish a simple system of insulin production ... -
Enhancement of the Physical Stability of Amorphous Sildenafil in a Binary Mixture, with either a Plasticizing or Antiplasticizing Compound
Tajber, Lidia; Knapik-Kowalczuk, Justyna; Chmiel, Krzysztof; Pacult, Justyna; Bialek, Klaudia; Paluch, Marian (2020)The main purpose of this paper was to evaluate the impact of both high- and low-Tg polymer additives on the physical stability of an amorphous drug, sildenafil (SIL). The molecular mobility of neat amorphous SIL was strongly ... -
An Enteric-Coated Polyelectrolyte Nanocomplex Delivers Insulin in Rat Intestinal Instillations when Combined with a Permeation Enhancer
Tajber, Lidia; Sladek, Svenja; McCartney, Fiona; Eskander, Mena; Dunne, David J.; Santos-Martinez, Maria Jose; Benetti, Federico; Brayden, David J. (2020)The use of nanocarriers is being researched to achieve oral peptide delivery. Insulin-associated anionic polyelectrolyte nanoparticle complexes (PECs) were formed that comprised hyaluronic acid and chitosan in an optimum ... -
Formation of low melting point binary systems comprising ketoprofen and an amide local anaesthetic
Tajber, Lidia (2021)Liquid forms of active pharmaceutical ingredients, ionic liquids (ILs) and deep eutectic mixtures (DEMs), offer several potential benefits in respect to advancing pharmaceutical formulations. The aim of this study was to ... -
Formation of stoichiometric and non-stoichiometric ionic liquid and cocrystal multicomponent phases of lidocaine with azelaic acid by changing counterion ratios
Tajber, Lidia (2021)Tuning of physicochemical properties of ionic liquids and crystalline materials is a challenge that opens up unlimited possibilities for expanding applications and controlling biological activity of pharmaceutical ... -
Formulation and characterisation of polyelectrolyte complex nanoparticles for the delivery of salmon calcitonin
Umerska, Anita Monika (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2013)The studies in this thesis explored the formulation of various polyelectrolyte complex nanoparticles as potential carriers for the delivery of macromolecules. The complexes were formed between a polyanion (hyaluroninc acid, ... -
Formulation, production and biointeraction of micro and nano particulates with potential for use in drug delivery
Li, Xue (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2009)The current study involved the preparation of a range of micro and nano particulates from known biocompatible pharmaceutical polymeric excipients: PLGA, chitosan and hyaluronic acid, using physical rather than chemical ... -
Freeze drying of polyelectrolyte complex nanoparticles: Effect of nanoparticle composition and cryoprotectant selection
Tajber, Lidia; Umerska, Anita; Paluch, Krzysztof J.; Santos Martinez, Maria-Jose; Corrigan, Owen I.; Medina, Carlos (2018)This work investigates the impact of nanoparticle (NP) composition and effectiveness of cryo-/lyo-protectants in a freeze drying process, which was employed to convert liquid dispersions of polyelectrolyte complex (PEC) ... -
Green Synthesis of Lidocaine Ionic Liquids and Salts: Mechanisms of Formation and Interactions in the Crystalline and Supercooled States
Tajber, Lidia (2020)Mechanochemistry has been recognized as an optimal route for the synthesis of ionic liquids incorporating active pharmaceutical ingredients (API-ILs) as it eliminates the need for large volumes of solvents and purification ... -
High-Pressure Dielectric Studies-a Way to Experimentally Determine the Solubility of a Drug in the Polymer Matrix at Low Temperatures
Tajber, Lidia (2021)In this work, we employed broad-band dielectric spectroscopy to determine the solubility limits of nimesulide in the Kollidon VA64 matrix at ambient and elevated pressure conditions. Our studies confirmed that the solubility ...