Browsing by Author "TIPTON, KEITH"
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Anti-inflammatory actions of a taurine analogue; ethane ?-sultam; in phagocytic cells; in vivo and in vitro
TIPTON, KEITH (Elsevier, 2011)The ability of a taurine prodrug, ethane ?-sultam, to reduce cellular inflammation has been investigated, in vitro, in primary cultures of alveolar macrophages and an immortilised N9 microglial cell line and in vivo in an ... -
Characterization of cinnamyl alcohol dehydrogenase of Helicobacter pylori. An aldehyde dismutating enzyme
KELLEHER, DERMOT P; TIPTON, KEITH; WINDLE, HENRY (John Wiley, 2005)Cinnamyl alcohol dehydrogenases (CAD; 1.1.1.195) catalyse the reversible conversion of p-hydroxycinnamaldehydes to their corresponding alcohols, leading to the biosynthesis of lignin in plants. Outside of plants their role ... -
First-in-class thyrotropin-releasing hormone (TRH)-based compound binds to a pharmacologically distinct TRH receptor subtype in human brain and is effective in neurodegenerative models.
WALSH, CATHAL; TIPTON, KEITH; KELLY, JULIE; HARDIMAN, ORLA; O'MARA, SHANE; CAMPBELL, MATTHEW; VAJDA, ALICE; GOBBO, OLIVIERO (2015) -
Functional Group and Substructure Searching as a Tool in Metabolomics
TIPTON, KEITH; MCDONALD, ANDREW (2008)Background: A direct link between the names and structures of compounds and the functional groups contained within them is important, not only because biochemists frequently rely on literature that uses a free-text format ... -
Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation
MCDONALD, ANDREW; HAYES, JERRARD; DAVEY, GAVIN; TIPTON, KEITH (2014)Protein N-glycosylation is a common post-translational modification that produces a complex array of branched glycan structures. The levels of branching, or antennarity, give rise to differential biological activities for ... -
GlycoForm and Glycologue: two software applications for the rapid construction and display of N-glycans from mammalian sources.
DAVEY, GAVIN; MCDONALD, ANDREW; TIPTON, KEITH (2010)Background: The display of N-glycan carbohydrate structures is an essential part of glycoinformatics. Several tools exist for building such structures graphically, by selecting from a palette of symbols or sugar names, ... -
Interaction of l-lysine and soluble elastin with the semicarbazide-sensitive amine oxidase in the context of its vascular-adhesion and tissue maturation functions
O'SULLIVAN, JEFFREY; TIPTON, KEITH (2010)The copper-containing quinoenzyme semicarbazide-sensitive amine oxidase (EC 1.4.3.21; SSAO) is a multifunctional protein. In some tissues, such as the endothelium, it also acts as vascular-adhesion protein 1 (VAP-1), which ... -
Recommendations for terminology and databases for biochemical thermodynamics
TIPTON, KEITH (Elsevier, 2011)Chemical equations are normally written in terms of specific ionic and elemental species and balance atoms of elements and electric charge. However, in a biochemical context it is usually better to write them with ionic ... -
Tracing metabolic pathways from enzyme data
TIPTON, KEITH; BOYCE, SINEAD J (2009)