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  • Characterisation of Innate Immune and Metabolic Roles of SARM1 in Mouse Macrophages. 

    Shanahan, Katharine Ann (Trinity College Dublin. School of Biochemistry & Immunology. Discipline of Biochemistry, 2022)
    Engagement of the NLRP3 inflammasome in response to injury or infection results in the activation of the pro-inflammatory protease, caspase-1. Cleavage of the caspase-1 substrate, gasdermin D (GSDMD), leads to the GSDMD ...