Browsing by Author "STEVENSON, NIGEL"
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Hepatitis C virus (HCV) induced suppressor of cytokine signalling (SOCS) 3 regulates proinflammatory tumour necrosis factor (TNF)-α responses.
O'FARRELLY, CLIONA; STEVENSON, NIGEL (2014)TNF-α is a proinflammatory cytokine, dramatically elevated during pathogenic infection and often responsible for inflammation-induced disease pathology. SOCS proteins are inhibitors of cytokine signaling and regulators of ... -
In vitro Blood Cell Responsiveness to IFN-alpha Predicts Clinical Response Independently of IL28B in Hepatitis C Virus Genotype 1 Infected Patients.
STEVENSON, NIGEL; O'FARRELLY, CLIONA; BOURKE, NOLLAIG (2014)BACKGROUND: Treatment with interferon-alpha (IFN-α) and ribavirin successfully clears hepatitis C virus (HCV) infection in 50% of patients infected with genotype 1. Addition of NS3-4A protease inhibitors (PIs) increases ... -
MicroRNA: master controllers of intracellular signaling pathways.
STEVENSON, NIGEL (Springer, 2015)Signaling pathways are essential intracellular networks that coordinate molecular outcomes to external stimuli. Tight regulation of these pathways is essential to ensure an appropriate response. MicroRNA (miRNA) is ... -
miR-19a: an effective regulator of SOCS3 and enhancer of JAK-STAT signalling.
STEVENSON, NIGEL; O'FARRELLY, CLIONA (2013)Suppressors of cytokine signalling (SOCS) proteins are classic inhibitors of the Janus kinase-signal transducer and activator of transcription (JAK-STAT) pathway. Many cytokines and pathogenic mediators induce expression ... -
Ribavirin Enhances IFN-α Signalling and MxA Expression: A Novel Immune Modulation Mechanism during Treatment of HCV
STEVENSON, NIGEL; KEOGH, CATHERINE; HEGARTY, JOHN; O'FARRELLY, CLIONA; BOURKE, NOLLAIG (2011)The nucleoside analogue Ribavirin significantly increases patient response to IFN-? treatment of HCV, by directly inhibiting viral replication. Recent studies indicate that Ribavirin also regulates immunity and we propose ... -
SOCS3 revisited: a broad regulator of disease, ready for therapeutic use?
STEVENSON, NIGEL (Springer, 2016-03-24)Since their discovery, SOCS have been characterised as regulatory cornerstones of intracellular signalling. While classically controlling the JAK/STAT pathway, their inhibitory effects are documented across several ... -
Suppressor of cytokine signalling (SOCS) 1 and 3 enhance cell adhesion and inhibit migration towards the chemokine eotaxin/CCL11
STEVENSON, NIGEL; LONG, AIDEEN; O'FARRELLY, CLIONA; ONG, SEOW (2010)Suppressors of cytokine signalling (SOCS) proteins regulate signal transduction, but their role in responses to chemokines remains poorly understood. We report that cells expressing SOCS1 and 3 exhibit enhanced adhesion ...