Browsing by Author "SHEILS, ORLA"
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Adenovirus 12 E1A gene detection by polymerase chain reaction in both the normal and coeliac duodenum.
LAWLESS, MATTHEW; KELLEHER, DERMOT; SHEILS, ORLA; O'FARRELLY, CLIONA (1994)A 12 amino acid sequence from the adenovirus 12 E1B protein is homologous at the protein level with a similar 12-mer derived from the wheat protein A-gliadin. It has been suggested that exposure to Ad 12 could sensitise ... -
Aspirin and P2Y<inf>12</inf> inhibition attenuate platelet-induced ovarian cancer cell invasion
SHEILS, ORLA; O'LEARY, JOHN; SPILLANE, CATHY (2015)Background: Platelet-cancer cell interactions play a key role in successful haematogenous metastasis. Disseminated malignancy is the leading cause of death among ovarian cancer patients. It is unknown why different ovarian ... -
Detection of a Tyrosine Phosphatase LAR on Intestinal Epithelial Cells and Intraepithelial Lymphocytes in the Human Duodenum.
KELLEHER, DERMOT P; MURPHY, ANNE; SHEILS, ORLA (Hindawi, 2005)Studies of tyrosine phosphorylation in the human duodenum have indicated that proliferating cells in the middle portion of the duodenal crypt were devoid of this feature, suggesting that tyrosine kinase activation is not ... -
Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays
MARTIN, CARA; O'LEARY, JOHN JAMES; SHEILS, ORLA; MURPHY, MAIREAD; O'TOOLE, SHARON (Elsevier, 2012)Autoantibodies represent an attractive biomarker for diagnostic assays principally due to the stability of immunoglobulin in patient serum facilitating measurement with conventional assays. Immune responses to tumorigenesis ... -
FOXA1 is a potential oncogene in anaplastic thyroid carcinoma
TONER, MARY ELIZABETH; SHEILS, ORLA (2009)Purpose: FOXA1 is a mammalian endodermal transcription factor belonging to the human forkhead box gene family that plays a role in certain tumor types. Here, we investigated the potential role of FOXA1 in human thyroid ... -
Identifying novel hypoxia-associated markers of chemoresistance in ovarian cancer
SHEILS, ORLA; O'LEARY, JOHN; GALLAGHER, MICHAEL; SPILLANE, CATHY (2015)Background: Ovarian cancer is associated with poor long-term survival due to late diagnosis and development of chemoresistance. Tumour hypoxia is associated with many features of tumour aggressiveness including increased ... -
An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines.
SHEILS, ORLA (2014)BACKGROUND: SOX2 is a core component of the transcriptional network responsible for maintaining embryonal carcinoma cells (ECCs) in a pluripotent, undifferentiated state of self-renewal. As such, SOX2 is an oncogenic ... -
An integrated analysis of the SOX2 microRNA response program in human pluripotent and nullipotent stem cell lines.
SHEILS, ORLA; O'LEARY, JOHN; GALLAGHER, MICHAEL; SPILLANE, CATHY (2014) -
Ligation of TLR7 on CD19(+) CD1d(hi) B cells suppresses allergic lung inflammation via regulatory T cells.
FALLON, PADRAIC; SHEILS, ORLA; HAMS, EMILY (2015)B cells have been described as having the capacity to regulate cellular immune responses and suppress inflammatory processes. One such regulatory B-cell population is defined as IL-10-producing CD19(+) CD1d(hi) cells. ... -
The MyD88+ phenotype is an adverse prognostic factor in epithelial ovarian cancer.
MARTIN, CARA; SHEILS, ORLA; SMYTH, PAUL; FINN, STEPHEN; O'LEARY, JOHN; GALLAGHER, MICHAEL; BATES, MARK; SPILLANE, CATHY (2014)The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential ... -
Platelet Adhesion and Degranulation Induce Pro-Survival and Pro-Angiogenic Signalling in Ovarian Cancer Cells
SMYTH, PAUL; O'LEARY, JOHN; O'TOOLE, SHARON; SPILLANE, CATHY; MARTIN, CARA; GALLAGHER, MICHAEL; NORRIS, LUCY; CONLON, NIAMH; MCEVOY, LYNDA MARIE; FFRENCH, GEORGE BRENDAN; STORDAL, BRITTA; KEEGAN, HELEN; FINN, STEPHEN; MCENEANEY, VICTORIA; SHEILS, ORLA; CROWLEY, DARRAGH (2011)Thrombosis is common in ovarian cancer. However, the interaction of platelets with ovarian cancer cells has not been critically examined. To address this, we investigated platelet interactions in a range of ovarian cancer ... -
Potential role of miR-9 and miR-223 in recurrent ovarian cancer
SHEILS, ORLA; O'LEARY, JOHN JAMES; O'TOOLE, SHARON; MARTIN, CARA (2008)Background: MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable ... -
Prevalence of human papillomavirus in men who have sex with men in the era of an effective vaccine; a call to act.
SMYTH, PAUL; O'LEARY, JOHN; SHEILS, ORLA (2014)OBJECTIVES: The incidence of human papillomavirus (HPV)-associated anal cancer is increasing. Men who have sex with men (MSM), particularly those coinfected with HIV, are disproportionately affected. Documenting the ... -
Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients.
SMYTH, PAUL; MARTIN, CARA; MCINERNEY, JAMIE KEVIN; ELBARUNI, SALAH AMRU; O'LEARY, JOHN; SALLEY, YVONNE; VENCKEN, SEBASTIAN; O'TOOLE, SHARON; AHERNE, SINEAD; SHEILS, ORLA; GALLAGHER, MICHAEL (2009)Background: Tumours with high proportions of differentiated cells are considered to be of a lower grade to those containing high proportions of undifferentiated cells. This property may be linked to the differentiation ... -
Tyrosine phosphorylation in the human duodenum.
KELLEHER, DERMOT P; SHEILS, ORLA (BMJ, 1995)Many growth factor receptors including the epidermal growth factor receptor function through tyrosine kinase activity. The aim of this study was to examine the constitutive level of tyrosine phosphorylation in the normal ...