Browsing by Author "Rowan, Michael"
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Aß Facilitates LTD at Schaffer Collateral Synapses Preferentially in the Left Hippocampus Rowan, Michael; O'Riordan, Kenneth J.; Hu, Neng-Wei (2018)Promotion of long-term depression (LTD) mechanisms by synaptotoxic soluble oligomers of amyloid-β (Aß) has been proposed to underlie synaptic dysfunction in Alzheimer’s disease (AD). Previously, LTD was induced by relatively ...
Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity Rowan, Michael; Hu, Neng-Wei; Corbett, Grant T.; Moore, Steven; Klyubin, Igor; O'Malley, Tiernan T.; Walsh, Dominic M.; Livesey, Frederick J. (2018)The early stages of Alzheimer’s disease are associated with synaptic dysfunction prior to overt loss of neurons. To identify extracellular molecules that impair synaptic plasticity in the brain, we studied the secretomes ...
Physiological activation of mGlu5 receptors supports the ion channel function of NMDA receptors in hippocampal LTD induction in vivo Rowan, Michael; O'Riordan, Kenneth J.; Hu, Neng-Wei (2018)Synaptic long-term depression (LTD) is believed to underlie critical mnemonic processes in the adult hippocampus. The roles of the metabotropic and ionotropic actions of glutamate in the induction of synaptic LTD by ...