Browsing by Author "Radomski, Marek"
Now showing items 1-2 of 2
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The design, synthesis and biological evaluation of novel barbiturate-based MMP inhibitors
Wang, Jun (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2010)Matrix metalloproteinases (MMPs) are a group of Zn-dependent endopeptidases that participate in many diseases. Two MMPs, MMP-2 and MMP-9, which are especially associated with inflammatory diseases and tumor metastasis have ... -
Triple negative breast cancer-derived extracellular-vesicles as naturally-occuring biomarkers and therapeutic delivery systems
O'Brien, Keith (Trinity College (Dublin, Ireland). School of Pharmacy & Pharmaceutical Sciences, 2015)Background: In Ireland, breast cancer is the most commonly diagnosed cancer among women; and of the breast cancer subtypes, triple-negative breast cancers (TNBC) are the most aggressive. TNBCs account for 15%-20% of breast ...