Browsing by Author "RYDER, SHEILA"
Now showing items 1-11 of 11
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A comparison of community pharmacy methadone services between Dublin and Glasgow: (1) Extent of service provision in 1997/8 and views of pharmacists on existing provision and future service developments.
RYDER, SHEILA (2004)Objectives: To determine the extent of pharmacists' participation in methadone services, type of services provided, views on current service provision and suggestions for future service developments. Methods and setting: ... -
Design template for a medication safety programme in an acute teaching hospital
RYDER, SHEILA (2012)Background: Very limited data have been published about the design of medication safety programmes in hospitals. Objective: To describe a template for the structure and operation of a medication safety programme in an ... -
The effect of providing feedback on inhaler technique and adherence from an electronic audio recording device, INCA?, in a community pharmacy setting: study protocol for a randomised controlled trial.
RYDER, SHEILA; REILLY, RICHARD; BOLAND, FRANCIS; RAPCAN, VILIAM; D'ARCY, SHONA (2016)Background: Poor adherence to inhaled medication may lead to inadequate symptom control in patients with respiratory disease. In practice it can be difficul t to identify poor adherence. We designed an acoustic recording ... -
Isosorbide-based cholinesterase inhibitors; replacement of 5-ester groups leading to increased stability
RYDER, SHEILA (2010)Isosorbide-2-carbamate-5-esters are highly potent and selective butyrylcholinesterase inhibitors with potential utility in the treatment of Alzheimer?s Disease (AD). They are stable in human plasma but in mouse plasma they ... -
Measuring and benchmarking safety culture: application of the safety attitudes questionnaire to an acute medical admissions unit.
RYDER, SHEILA (2009)Objectives: To assess the safety culture in an acute medical admissions unit (AMAU) of a teaching hospital in order to benchmark results against international data and guide a unit-based, integrated, risk management ... -
N1-dansyl-spermine: a potent polyamine antagonist.
RYDER, SHEILA (2004)The potential polyamine antagonist action of N1-dansyl-spermine (a potent NMDA antagonist) was assessed in two in vivo mouse models of polyamine action. Co-administration of N1-dansyl-spermine (2?10 ?g, i.c.v.) with spermine ... -
Novel isosorbide di-ester compounds as inhibitors of acetylcholinesterase
RYDER, SHEILA (2008)We report herein that a variety of isosorbide di-esters, previously reported to be novel substrates for butyrylcholinesterase (BuChE, EC 3.1.1.8), are in fact inhibitors of the homologous enzyme acetylcholinesterase (AChE), ... -
Pharmacological effects of a novel isosorbide-based butyrylcholinesterase inhibitor
RYDER, SHEILA (2008)Isosorbide-2-benzylcarbamate-5-benzoate, a novel butyrylcholinesterase inhibitor, shows interspecies variation in its inhibitory activity (IC50 of 4.3 nM for human plasma butyrylcholinesterase, but 1.09 ?M for mouse plasma ... -
Profiling harmful medication errors in an acute Irish teaching hospital.
RYDER, SHEILA (2012)Background: Medication error reporting systems in hospitals are faced with the challenge of processing vast numbers of reports which identify a myriad of safety issues. With such large volumes of data and limited resources ... -
Single oral dose study of two isosorbide-based aspirin prodrugs in the dog
RYDER, SHEILA (2003)The objective of this study was to compare two aspirin prodrugs, isosorbide diaspirinate (ISDA) and a nitroaspirin (ISMNA), with aspirin in terms of effects on dog platelet function after administration of a single oral ... -
Tumour vasculature targeting agents in hybrid/conjugate drugs.
RYDER, SHEILA; WALSH, JOHN (2013)Tumour vasculature targeting has been a very active area of cancer drug discovery over the last decade. Growth of solid tumours beyond a certain point requires a sufficient blood supply in order for them to develop and ...