Browsing by Author "RADOMSKI, MAREK"
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Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells inflammatory and cytotoxicity effects.
RADOMSKI, MAREK; MEDINA MARTIN, CARLOS (2011)BACKGROUND: The purpose of this study was to investigate the mechanism of noxious effects of amorphous silica nanoparticles on human endothelial cells. METHODS: Nanoparticle uptake was examined by transmission electron ... -
Analysis of platelet function: role of microfluidics and nanodevices
RADOMSKI, MAREK; MEDINA MARTIN, CARLOS; SANTOS-MARTINEZ, MARIA (2011)Platelet aggregation is essential for vascular haemostasis and thrombosis. To improve the therapy of arterial thrombotic disorders and identify novel therapeutic targets it is imperative to study basic mechanisms of platelet ... -
Approaches to the safety assessment of engineered nanomaterials (ENM) in food
RADOMSKI, MAREK (Elsevier, 2011)A systematic, tiered approach to assess the safety of engineered nanomaterials (ENMs) in foods is presented. The ENM is first compared to its non-nano form counterpart to determine if ENM-specific assessment is required. ... -
CdTe quantum dots induce activation of human platelets: implications for particle hemocompatibility.
RADOMSKI, MAREK; VOLKOV, YURI; RADOMSKI, MAREK; VOLKOV, YURI (2015)New nanomaterials intended for systemic administration have raised concerns regarding their biocompatibility and hemocompatibility. Quantum dots (QD) nanoparticles have been used for diagnostics, and recent work suggests ... -
Exosomes from triple-negative breast cancer cells can transfer phenotypic traits representing their cells of origin to secondary cells
RADOMSKI, MAREK (2013)Background Triple-negative breast cancer (TNBC) accounts for 15–20% of breast cancers but is responsible for a disproportionate number of deaths. We investigated the relevance, in TNBC, of nano-sized exosomes expelled ... -
Matrix metalloproteinase-9 modulates intestinal injury in rats with transmural colitis.
RADOMSKI, MAREK; MEDINA MARTIN, CARLOS (2006)Proteolysis and degradation of extracellular matrix by metalloproteinases (MMPs) may contribute to intestinal injury in inflammatory bowel disease. In the present study, we investigated the pathogenic role of gelatinases ... -
Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets
RADOMSKI, MAREK; SANTOS-MARTINEZ, MARIA (2012)OBJECTIVES: Aspirin is the mainstay of anti-platelet therapy in the secondary prevention of cardiovascular disease. However, problems with aspirin safety and resistance demand clinical strategies based on multiple ... -
Mechanisms of platelet-stimulated colon cancer invasion: role of clusterin and thrombospondin 1 in regulation of the P38MAPK-MMP-9 pathway.
SANTOS-MARTINEZ, MARIA; RADOMSKI, MAREK; MEDINA MARTIN, CARLOS (2014) -
MMP inhibition by barbiturate homodimers
RADOMSKI, MAREK; MEDINA MARTIN, CARLOS (2013)We have studied some homodimeric compounds derived from 5-homopiperazine substituted pyrimidine triones (barbiturates) with linkers in the range 2-20 carbon atoms. The compounds were designed to be capable of resisting ... -
N-subsituted homopiperazine barbiturates as gelatinase inhibitors
RADOMSKI, MAREK; WANG, JUN; MEDINA MARTIN, CARLOS; GILMER, JOHN (2011)Matrix metalloproteinases are implicated in a wide range of pathophysiological processes and potent selective inhibitors for these enzymes continue to be eagerly sought. 5,5-Disubstituted barbiturates hold promise as ... -
Nanoparticles: pharmacological and toxicological significance
RADOMSKI, MAREK; SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS; CORRIGAN, OWEN (2007) -
Nitric oxide-matrix metaloproteinase-9 interactions: Biological and pharmacological significance: NO and MMP-9 interactions
RADOMSKI, MAREK; MEDINA MARTIN, CARLOS (2014) -
Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride
RADOMSKI, MAREK; SANTOS-MARTINEZ, MARIA (2014)BACKGROUND: Silver nanoparticles (AgNPs) and fluoride (F) are pharmacological agents widely used in oral medicine and dental practice due to their anti-microbial/anti-cavity properties. However, risks associated with ... -
Pharmacological and toxicological effects of co-exposure of human gingival fibroblasts to silver nanoparticles and sodium fluoride
MEDINA MARTIN, CARLOS; RADOMSKI, MAREK (2014) -
Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry
RADOMSKI, MAREK; SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS (2015) -
Platelet aggregation induced by Caco-2 cells: regulation by matrix metalloproteinase-2 and adenosine diphosphate
RADOMSKI, MAREK; SANTOS-MARTINEZ, MARIA; MEDINA MARTIN, CARLOS (2006)Formation of tumor cell-platelet aggregates facilitates hematogenous metastases. However, molecular mechanisms implicated in tumor cell-induced platelet aggregation (TCIPA) in colon cancer are unclear. To investigate ... -
Platelets, photosensitizers and PDT
RADOMSKI, MAREK; SENGE, MATHIAS (2013)Photodynamic therapy (PDT) has both direct cell and indirect vascular effects. Both are well established and the latter has given rise to specifically target angiogenesis in PDT treatments. While the vascular effects are ... -
Polystyrene nanoparticles activate ion transport in human airway epithelial cells
RADOMSKI, MAREK; MCCARTHY, JOSEPH (2011)Background: Over the last decade, nanotechnology has provided researchers with new nanometer materials, such as nanoparticles, which have the potential to provide new therapies for many lung diseases. In this study, we ... -
Role of Matrix Metalloproteinases in Intestinal Inflammation
MEDINA MARTIN, CARLOS; RADOMSKI, MAREK (2006) -
Selective PKCalpha inhibition uncouples platelet angiogenesis promotion from collagen-induced aggregation
RADOMSKI, MAREK (2013)Platelets promote angiogenesis by releasing angiogenesis-regulating factors from their α-granules upon aggregation. This effect has both physiologic and pathologic significance as it may contribute to carcinogenesis. ...