Browsing by Author "QUINN, SUSAN"
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Bruton's Tyrosine Kinase Mediates the Synergistic Signalling between TLR9 and the B Cell Receptor by Regulating Calcium and Calmodulin
DOYLE, SARAH; O'NEILL, LUKE; QUINN, SUSAN (2013)B cells signal through both the B cell receptor (BCR) which binds antigens and Toll-like receptors (TLRs) including TLR9 which recognises CpG DNA. Activation of TLR9 synergises with BCR signalling when the BCR and TLR9 ... -
Crystallographic, 1H NMR and CD studies of sterically strained thiourea anion receptors possessing two stereogenic centres
GUNNLAUGSSON, THORFINNUR; QUINN, SUSAN; KRUGER, PAUL; MCCABE, THOMAS (2009)The synthesis and structural characterisation of three chiral bis-naphthalene thiourea receptors (1?3) derived from (R)-(+)-1-(1-naphthyl)ethylamine and (S)-(?)-1-(1-naphthyl)ethylamine are reported along with spectroscopic ... -
IL-10 inhibits miR-155 induction by Toll-like receptors.
O'NEILL, LUKE; DOYLE, SARAH; MCCOY, CLAIRE; SHEEDY, FREDERICK JOHN; QUINN, SUSAN; SHEEDY, FREDERICK (2010)IL-10 is a potent anti-inflammatory cytokine that is crucial for down-regulating pro-inflammatory genes which are induced by Toll-like Receptor (TLR) signalling. In this study we have examined whether modulation of micro-RNAs ... -
Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15.
DOYLE, SARAH; O'NEILL, LUKE; QUINN, SUSAN (2013)n this study we describe a previously unreported function for NFκB2, an NFκB family transcription factor, in antiviral immunity. NFκB2 is induced in response to poly(I:C), a mimic of viral dsRNA. Poly(I:C), acting via TLR3, ... -
Promyelocytic leukemia protein interacts with the apoptosis-associated speck-like protein to limit inflammasome activation
O'NEILL, LUKE; QUINN, SUSAN; BOURKE, NOLLAIG; CORR, SINEAD (2014)The apoptosis-associated speck-like protein containing a caspase-activating recruitment domain (ASC) is an essential component of several inflammasomes, multiprotein complexes that regulate caspase-1 activation and ... -
The role of Ets2 transcription factor in the induction of microRNA-155 by LPS, and its targeting by IL-10.
O'NEILL, LUKE; MCCOY, CLAIRE; QUINN, SUSAN (2014)MicroRNA-155 (miR-155) is highly expressed in many cancers such as B cell lymphomas and myeloid leukaemia, and inflammatory disorders such as rheumatoid arthritis, atopic dermatitis and multiple sclerosis. The role ... -
A Study of the pH Dependence of Electronically Excited Guanosine Compounds by Picosecond Time-resolved Infrared Spectroscopy
KELLY, JOHN MOFFAT; QUINN, SUSAN (2009)The photophysical properties of 5?-guanosine monophosphate (5?-GMP) and polyguanylic acid {poly(G)} in D2O solutions of varying pH have been studied using picosecond transient infrared absorption spectroscopy. Whereas ...