Browsing by Author "Prina Mello, Adriele"
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Asymmetric-flow field-flow fractionation for measuring particle size, drug loading and (in)stability of nanopharmaceuticals. The joint view of European Union Nanomedicine Characterization Laboratory and National Cancer Institute - Nanotechnology Characterization Laboratory
Prina Mello, Adriele (2021)Asymmetric-flow field-flow fractionation (AF4) has been recognized as an invaluable tool for the characterisation of particle size, polydispersity, drug loading and stability of nanopharmaceuticals. However, the application ... -
Comparing the Effects of Intracellular and Extracellular Magnetic Hyperthermia on the Viability of BxPC-3 Cells
Prina Mello, Adriele (2020)Magnetic hyperthermia involves the use of iron oxide nanoparticles to generate heat in tumours following stimulation with alternating magnetic fields. In recent times, this treatment has undergone numerous clinical trials ... -
Halloysite- and Montmorillonite-Loaded Scaffolds as Enhancers of Chronic Wound Healing
Prina Mello, Adriele (2020)The increase in life expectancy and the increasing prevalence of diabetic disease and venous insufficiency lead to the increase of chronic wounds. The prevalence of ulcers ranges from 1% in the adult population to 3–5% in ... -
Immunotoxicity Considerations for Next Generation Cancer Nanomedicines
Lysaght, Joanne; Prina Mello, Adriele (2019)Although interest and funding in nanotechnology for oncological applications is thriving, translating these novel therapeutics through the earliest stages of preclinical assessment remains challenging. Upon intravenous ... -
In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models-A Perspective.
Movia, Dania; Prina Mello, Adriele (2020)When assessing the risk and hazard of a non-pharmaceutical compound, the first step is determining acute toxicity, including toxicity following inhalation. Inhalation is a major exposure route for humans, and the respiratory ... -
Induction of protein citrullination and auto-antibodies production in murine exposed to nickel nanomaterials.
Volkov, Yuri; Gray, Steven; Prina Mello, Adriele (2018) -
Investigating the Potential and Pitfalls of EV-Encapsulated MicroRNAs as Circulating Biomarkers of Breast Cancer
Prina Mello, Adriele (2020)Extracellular vesicles (EVs) shuttle microRNA (miRNA) throughout the circulation and are believed to represent a fingerprint of the releasing cell. We isolated and characterized serum EVs of breast tumour-bearing animals, ... -
Magnetic Nanoparticles in Cancer Theranostics.
Prina Mello, Adriele; Volkov, Yuri (2015) -
Measuring particle concentration of multimodal synthetic reference materials and extracellular vesicles with orthogonal techniques: Who is up to the challenge?
Prina Mello, Adriele (2021)The measurement of physicochemical properties of polydisperse complex biological samples, for example, extracellular vesicles, is critical to assess their quality, for example, resulting from their production and isolation ... -
Measuring particle size distribution and mass concentration of nanoplastics and microplastics: addressing some analytical challenges in the sub-micron size range
Prina Mello, Adriele; Vella, Gabriele; Savage, J.; Hannon, Gary (2021)Hypothesis: The implementation of the proposal from the European Chemical Agency (ECHA) to restrict the use of nanoplastics (NP) and microplastics (MP) in consumer products will require reliable methods to perform size and ... -
Metastatic disease in head & neck oncology
Prina Mello, Adriele (2020)The head and neck district represents one of the most frequent sites of cancer, and the percentage of metastases is very high in both loco-regional and distant areas. Prognosis refers to several factors: a) stage of disease; ... -
Multiplex profiling identifies clinically relevant signalling proteins in an isogenic prostate cancer model of radioresistance
Bates, Mark; Manecksha, Rustom; Marignol, Laure; Prina Mello, Adriele (2019)The exact biological mechanism governing the radioresistant phenotype of prostate tumours at a high risk of recurrence despite the delivery of advanced radiotherapy protocols remains unclear. This study analysed the protein ... -
Nanomedicine applied to translational oncology: A future perspective on cancer treatment.
Prina Mello, Adriele; Lysaght, Joanne; Movia, Dania; Reynolds, John (2016)The high global incidence of cancer is associated with high rates of mortality and morbidity worldwide. By taking advantage of the properties of matter at the nanoscale, nanomedicine promises to develop innovative drugs ... -
Nanotechnology in pulmonary medicine
Prina Mello, Adriele (2020)Nanotechnology in medicine-nanomedicine-is extensively employed to diagnose, treat, and prevent pulmonary diseases. Over the last few years, this brave new world has made remarkable progress, offering opportunities to ... -
Preclinical Development of Orally Inhaled Drugs (OIDs)-Are Animal Models Predictive or Shall We Move Towards In Vitro Non-Animal Models?
Movia, Dania; Prina Mello, Adriele (2020)Respiratory diseases constitute a huge burden in our society, and the global respiratory drug market currently grows at an annual rate between 4% and 6%. Inhalation is the preferred administration method for treating ... -
Preparation from a revisited wet chemical route of phase-pure, monocrystalline and SHG-efficient BiFeO<inf>3</inf>nanoparticles for harmonic bio-imaging
Gounko, Iouri; Prina Mello, Adriele; Volkov, Yuri (2018) -
Proinflammatory Effect of Carbon-Based Nanomaterials: In Vitro Study on Stimulation of Inflammasome NLRP3 via Destabilisation of Lysosomes
Prina Mello, Adriele; Volkov, Yuri (2020)Carbon‐based nanomaterials (C‐BNM) have recently attracted an increased attention as the materials with potential applications in industry and medicine. Bioresistance and proinflammatory potential of C‐BNM is the main ... -
Risk management framework for nano-biomaterials used in medical devices and advanced therapy medicinal products
Prina Mello, Adriele (2020)The convergence of nanotechnology and biotechnology has led to substantial advancements in nano-biomaterials (NBMs) used in medical devices (MD) and advanced therapy medicinal products (ATMP). However, there are concerns ... -
Silver nanoparticles as a medical device in healthcare settings: a five-step approach for candidate screening of coating agents
Smith, Stephen; Volkov, Yuri; Prina Mello, Adriele (2018)Silver nanoparticle-based antimicrobials can promote a long lasting bactericidal effect without detrimental toxic side effects. However, there is not a clear and complete protocol to define and relate the properties of ... -
Sizing up the Next Generation of Nanomedicines
Prina Mello, Adriele (2019)During the past two decades the nanomedicine field has experienced significant progress. To date, over sixty nanoparticle (NP) formulations have been approved in the US and EU while many others are in clinical or preclinical ...