Browsing by Author "Prendergast, Patrick"
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Annual Review 2012-2013
Prendergast, Patrick (Trinity College Dublin, IE, 2014) -
Annual Review 2013-2014
Prendergast, Patrick (Trinity College Dublin, 2015) -
Annual Review 2014-2015
Prendergast, Patrick (Trinity College Dublin, 2016) -
Annual Review 2015-2016
Prendergast, Patrick (Trinity College Dublin , the University of Dublin, 2016) -
Annual Review 2016-2017
Prendergast, Patrick (Trinity College Dublin , the University of Dublin, 2017) -
Annual Review 2017-2018
Prendergast, Patrick (Trinity College Dublin , the University of Dublin, 2018) -
Annual Review 2018-2019
Prendergast, Patrick (Trinity College Dublin - University of Dublin, 2019-10) -
Biophysical stimuli induced by passive movements compensate for lack of skeletal muscle during embryonic skeletogenesis
Prendergast, Patrick; Murphy, Paula (University of Edinburgh (datashare), 2011)In genetically modified mice with abnormal skeletal muscle development, bones and joints are differentially affected by the lack of skeletal muscle.We hypothesise that unequal levels of biophysical stimuli in the ... -
A comparison of strain and fluid shear stress in stimulating bone cell responses - a computational and experimental study
Prendergast, Patrick (2005)Bone undergoes continuous remodeling in response to mechanical loading. However, the underlying mechanisms by which bone cells respond to their changing mechanical environment, that is, strain in the load-bearing matrix ... -
A comparison of the osteogenic potential of adult rat mesenchymal stem cells cultured in 2-D and on 3-D collagen glycosaminoglycan scaffolds.
Prendergast, Patrick; CAMPBELL, VERONICA; FARRELL, ERIC; BYRNE, ELAINE (2007)Adult mesenchymal stem cells (MSCs) have the capability to differentiate along several lineages including those of bone, cartilage, tendon and muscle, thus offering huge potential for the field of tissue engineering. The ... -
Computational simulation methodologies for mechanobiological modelling: a cell-centred approach to neointima development in stents.
Prendergast, Patrick; LENNON, ALEXANDER; KELLY, DANIEL; BOYLE, COLIN; EARLY, MICHAEL; LALLY, CAITRIONA (2010)The design of medical devices could be very much improved if robust tools were available for computational simulation of tissue response to the presence of the implant. Such tools require algorithms to simulate the response ... -
Computer simulating a clinical trial of a load-bearing implant: example of an intramedullary prosthesis
Prendergast, Patrick (2011)Computational modelling is becoming ever more important for obtaining regulatory approval for new medical devices. An accepted approach is to infer performance in a population from an analysis conducted in an idealized or ... -
Corroboration of computational models for mechanoregulated stem cell differentiation.
Prendergast, Patrick (2015)Do computational models contribute to progress in mechanobiology? Jacobs and Kelly (in Advances on Modelling in Tissue Engineering, p. 1–14, 2011) suggest that they do, but at the same time propose a limitation in the ... -
Developing bones are differentially affected by compromised skeletal muscle formation
Prendergast, Patrick; Murphy, Paula (University of Edinburgh (datashare), 2010)Mechanical forces are essential for normal adult bone function and repair, but the impact of prenatal muscle contractions on bone development remains to be explored in depth in mammalian model systems. In this study, we ... -
Dynamic patterns of mechanical stimulation co-localise with growth and cell proliferation during morphogenesis in the avian embryonic knee joint
Prendergast, Patrick; Murphy, Paula (University of Edinburgh (datashare), 2011)Muscle contractions begin in early embryonic life, generating forces that regulate the correct formation of the skeleton. In this paper we test the hypothesis that the biophysical stimulation generated by muscle forces may ... -
Effect of membrane stiffness and cytoskeletal element density on mechanical stimuli within cells: an analysis of the consequences of ageing in cells
Campbell, Veronica; Prendergast, Patrick (2015)A finite element model of a single cell was created and used to compute the biophysical stimuli generated within a cell under mechanical loading. Major cellular components were incorporated in the model: the membrane, ... -
Four decades of finite element analysis of orthopaedic devices: Where are we now and what are the opportunities?
Prendergast, Patrick (2015)Finite element has been used for more than four decades to study and evaluate the mechanical behaviour total joint replacements. In Huiskes seminal paper “Failed innovation in total hip replacement: diagnosis and proposals ... -
Global Relations Strategy
Ohlmeyer, Jane; Prendergast, Patrick (Trinity College Dublin, IE, 2013) -
Grand Canal Innovation District A Vision for Ireland
Prendergast, Patrick; O'Brien, Diarmuid (Trinity College Dublin , the University of Dublin, 2018-07)Trinity is spearheading the development of the Grand Canal Innovation District concept in collaboration with the other Dublin universities and the broader enterprise community. We are outlining our vision and issuing ... -
Grand Canal Innovation District Manifesto
Prendergast, Patrick; O'Brien, Diarmuid (Trinity College Dublin , the University of Dublin, 2018-07)Trinity College Dublin, the highest internationally ranked university in Ireland has spearheaded the development of the Grand Canal Innovation District concept.This document outlines our vision and serves as a call ...