Browsing by Author "PIDGEON, GRAHAM"
Now showing items 1-14 of 14
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COX-2 protects against thrombosis of the retinal vasculature in a mouse model of proliferative retinopathy.
PIDGEON, GRAHAM (Molecular Vision, 2006)Purpose: Cyclooxygenases (COX-1 and COX-2) and prostaglandins regulate angiogenesis in several settings, including cancer and ischemia. In the eye, both selective inhibitors of COX-2 and nonselective COX inhibitors are ... -
COX-Derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention
REYNOLDS, JOHN; O'SULLIVAN, JACINTHA; CATHCART, MARY CLARE; PIDGEON, GRAHAM; O'BYRNE, KEN (Elsevier, 2012)Arachidonic acid metabolism through cyclooxygenase (COX) pathways leads to the generation of biologically active eicosanoids. Eicosanoid expression levels vary during development and progression of gastrointestinal (GI) ... -
Elevated Tumor Expression of PAI-1 and SNAI2 in Obese Esophageal Adenocarcinoma Patients and Impact on Prognosis.
LYSAGHT, JOANNE; REYNOLDS, JOHN; PIDGEON, GRAHAM (2012) -
Expression of neuroepithelial transforming gene 1 is enhanced in oesophageal cancer and mediates an invasive tumour cell phenotype.
PIDGEON, GRAHAM (2013)Introduction Neuroepithelial Transforming Gene 1 (NET1) is a well characterised oncoprotein and a proven marker of an aggressive phenotype in a number of cancers, including gastric adenocarcinoma. We aimed to investigate ... -
Long-term activation of the pro-coagulant response after neoadjuvant chemoradiation and major cancer surgery.
PIDGEON, GRAHAM; REYNOLDS, JOHN; MAHER, STEPHEN; WHITE, BARRY; O'DONNELL, JAMES (2010)Background: The association between cancer, major surgery and venous thromboembolism (VTE) is well established. Multimodal therapy is increasingly being used as standard treatment for localised gastrointestinal ... -
Mechanisms controlling cell cycle arrest and induction of apoptosis after 12-lipoxygenase inhibition in prostate cancer cells.
PIDGEON, GRAHAM (American Association for Cancer Research, 2002)Extensive studies have implicated the role of dietary fatty acids in prostatecancer progression. Platelet-type 12-Lipoxygenase (12-LOX) has beenshown to regulate growth, metastasis, and angiogenesis of prostate cancer. The ... -
The mTOR pathway in obesity driven gastrointestinal cancers: Potential targets and clinical trials.
PIDGEON, GRAHAM (2016)The mechanistic target of rapamycin (mTOR) is a crucial point of convergence between growth factor signalling, metabolism, nutrient status and cellular proliferation. The mTOR pathway is heavily implicated in the progression ... -
Overexpression of platelet-type 12-lipoxygenase promotes tumor cell survival by enhancing alpha(v)beta(3) and alpha(v)beta(5) integrin expression.
PIDGEON, GRAHAM (American Heart Association, 2003)Background? Pulmonary hypertension induced by chronic hypoxia is characterized by thickening of pulmonary artery walls, elevated pulmonary vascular resistance, and right-heart failure. Prostacyclin analogues reduce pulmonary ... -
Pro-inflammatory and tumour proliferative properties of excess visceral adipose tissue
ALLOTT, EMMA; PIDGEON, GRAHAM; LYSAGHT, JOANNE; REYNOLDS, JOHN; DONOHOE, CLAIRE; HOWARD, JULIA MARY; RAVI, NARAYANASAMY; CASEY, RORY (2011)Obesity has been associated with increased incidence and mortality of oesophageal and colorectal adenocarcinoma. Excess central adiposity may drive this association through an altered inflammatory milieu. Utilizing a unique ... -
Prognostic significance of neuroepithelial transforming gene 1 in adenocarcinoma of the oesophagogastric junction.
CATHCART, MARY; PIDGEON, GRAHAM; REYNOLDS, JOHN; MULDOON, CIAN (2014)BACKGROUND: Neuroepithelial transforming gene 1 (NET1) mediates tumour invasion and metastasis in a number of cancers, including gastric adenocarcinoma. It is an indicator of poor prognosis in breast cancer and glioma. ... -
The role of endotoxin/lipopolysaccharide in surgically induced tumour growth in a murine model of metastatic disease
PIDGEON, GRAHAM (Nature Publishing Group, 1999)Surgical removal of a primary tumour is often followed by rapid growth of previously dormant metastases. Endotoxin or lipopolysaccharide, a cell wall constituent of Gram-negative bacteria, is ubiquitously present in air ... -
Vascular endothelial growth factor is an autocrine growth factor, signaling through neuropilin-1 in non-small cell lung cancer
GATELY, KATHY; O'BYRNE, KEN; PIDGEON, GRAHAM; GRAY, STEVEN (2015)Background: The VEGF pathway has become an important therapeutic target in lung cancer, where VEGF has long been established as a potent pro-angiogenic growth factor expressed by many types of tumors. While Bevacizumab ...