Browsing by Author "O'TOOLE, SHARON"
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Carboplatin and taxol resistance develops more rapidly in functional BRCA1 compared to dysfunctional BRCA1 ovarian cancer cells
O'TOOLE, SHARON; O'LEARY, JOHN; BUSSCHOTS, STEVEN (2014)A major risk factor for ovarian cancer is germline mutations of BRCA1/2. It has been found that (80%) of cellular models with acquired platinum or taxane resistance display an inverse resistance relationship, that is ... -
CD10-/ALDH- cells are the sole cisplatin-resistant component of a novel ovarian cancer stem cell network. Cell Death & Disease
GALLAGHER, MICHAEL; O'TOOLE, SHARON; BATES, MARK (2017) -
Epitope presentation is an important determinant of the utility of antigens identified from protein arrays in the development of autoantibody diagnostic assays
MARTIN, CARA; O'LEARY, JOHN JAMES; SHEILS, ORLA; MURPHY, MAIREAD; O'TOOLE, SHARON (Elsevier, 2012)Autoantibodies represent an attractive biomarker for diagnostic assays principally due to the stability of immunoglobulin in patient serum facilitating measurement with conventional assays. Immune responses to tumorigenesis ... -
Human papillomavirus detection and genotyping, by HC2, Full-Spectrum HPV and Molecular Beacon Real-Time HPV assay in an Irish colposcopy clinic
O'TOOLE, SHARON; KEEGAN, HELEN (2014)Cervical screening programmes are moving towards HPV testing as part of the screening process and as a triage for colposcopy. Three HPV detection methods were evaluated using cervical cytology specimens from colposcopy ... -
The MyD88+ Phenotype Is an Adverse Prognostic Factor in Epithelial Ovarian Cancer.
O'NEILL, LUKE; GLEESON, NOREEN; O'TOOLE, SHARON; O'BYRNE, KEN; O'LEARY, JOHN; SMYTH, PAUL (2014)The prognosis of epithelial ovarian cancer is poor in part due to the high frequency of chemoresistance. Recent evidence points to the Toll-like receptor-4 (TLR4), and particularly its adaptor protein MyD88, as one potential ... -
Potential role of miR-9 and miR-223 in recurrent ovarian cancer
SHEILS, ORLA; O'LEARY, JOHN JAMES; O'TOOLE, SHARON; MARTIN, CARA (2008)Background: MicroRNAs (miRNAs) are small, noncoding RNAs that negatively regulate gene expression by binding to target mRNAs. miRNAs have not been comprehensively studied in recurrent ovarian cancer, yet an incurable ... -
Regulation of microRNA biosynthesis and expression in 2102Ep embryonal carcinoma stem cells is mirrored in ovarian serous adenocarcinoma patients.
SMYTH, PAUL; MARTIN, CARA; MCINERNEY, JAMIE KEVIN; ELBARUNI, SALAH AMRU; O'LEARY, JOHN; SALLEY, YVONNE; VENCKEN, SEBASTIAN; O'TOOLE, SHARON; AHERNE, SINEAD; SHEILS, ORLA; GALLAGHER, MICHAEL (2009)Background: Tumours with high proportions of differentiated cells are considered to be of a lower grade to those containing high proportions of undifferentiated cells. This property may be linked to the differentiation ...