Browsing by Author "O'Sullivan, Jeffrey"

Now showing items 1-8 of 8

    • A study of the multiple functions and interactions of semicarbazide sensitive amine oxidase 

      O'Sullivan, Jeffrey (Trinity College (Dublin, Ireland). School of Biochemistry and Immunology, 2005)
      This thesis focuses on three of the recognised multiple functions of mammalian semicarbazide sensitive amine oxid ase (SSAO) and the contribution of monoamine oxidase (MAO) to some of these. SSAO is a vascular-adhesion ...

    • Autophagy as a therapeutic target to enhance chemotherapy in oral squamous cell carcinoma 

      Anderson, Aisling (Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2021)
      Oral cancer is the 15th most common cancer worldwide and oral squamous cell carcinoma accounts for 90% of oral cancer cases. Current therapeutic interventions for OSCC include surgical intervention with radiation therapy ...

    • Investigations into the development, diagnosis and treatment of oral cancer 

      O'Callaghan, Katherine (Trinity College (Dublin, Ireland). School of Dental Science, 2015)
      Oral cancer is the sixth most common cancer in the world and has one of the highest mortality rates primarily due to the disease being largely asymptomatic until the latter stages. It is among one of the major worldwide ...

    • The multi-faceted effects of ethanol exposure on oral dysplastic and cancer cells. 

      O'Grady, Isabel Lucy (Trinity College Dublin. School of Dental Sciences. Discipline of Dental Science, 2024)
      Oral cancers (OC) are cancers that arise in several regions within the oral cavity such as the lips, gums, tongue, lining of the cheeks, and the floor or roof of the mouth. Approximately 400,000 cases were diagnosed worldwide ...

    • Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, 2 Synthesis, Structural Analysis, and Biological Evaluation 

      Zisterer, Daniela; Kelly, Vincent; O'Sullivan, Jeffrey (2020)
      Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we report the development of a series of spiroindoline-based HDAC6 ...

    • Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents 

      Zisterer, Daniela; O'Sullivan, Jeffrey; Brindisi, Margherita; Ulivieri, Cristina; Alfano, Gloria; Gemma, Sandra; de Asís Balaguer, Francisco; Khan, Tuhina; Grillo, Alessandro; Chemi, Giulia; Menchon, Grégory; Prota, Andrea E.; Olieric, Natacha; Lucena-Agell, Daniel; Barasoain, Isabel; Fernando Diaz, J.; Nebbioso, Angela; Conte, Mariarosaria; Lopresti, Ludovica; Magnano, Stefania; Amet, Rebecca; Kinsella, Paula; Ibrahim, Ola; Morbidelli, Lucia; Spaccapelo, Roberta; Baldari, Cosima; Butini, Stefania; Novellino, Ettore; Campiani, Giuseppe; Altucci, Lucia; Steinmetz, Michel O.; Brogi, Simone (2019)
      Microtubule-targeting agents (MTAs) are a class of clinically successful anti-cancer drugs. The emergence of multidrug resistance to MTAs imposes the need for developing new MTAs endowed with diverse mechanistic properties. ...