Browsing by Author "O'SULLIVAN, JACINTHA"
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A Barrett's esophagus registry of over 1000 patients from a specialist center highlights greater risk of progression than population-based registries and high risk of low grade dysplasia.
REYNOLDS, JOHN; O'SULLIVAN, JACINTHA; RAVI, NARAYANASAMY (2015) -
COX-Derived prostanoid pathways in gastrointestinal cancer development and progression: Novel targets for prevention and intervention
REYNOLDS, JOHN; O'SULLIVAN, JACINTHA; CATHCART, MARY CLARE; PIDGEON, GRAHAM; O'BYRNE, KEN (Elsevier, 2012)Arachidonic acid metabolism through cyclooxygenase (COX) pathways leads to the generation of biologically active eicosanoids. Eicosanoid expression levels vary during development and progression of gastrointestinal (GI) ... -
Decreased Mitochondrial DNA Mutagenesis in Human Colorectal Cancer
O'SULLIVAN, JACINTHA (2012)Genome instability is regarded as a hallmark of cancer. Human tumors frequently carry clonally expanded mutations in their mitochondrial DNA (mtDNA), some of which may drive cancer progression and metastasis. The high ... -
Dendritic cell inhibition correlates with survival of colorectal cancer patients on bevacizumab treatment.
O'SULLIVAN, JACINTHA (2012)we demonstrated that dendritic cell (DC) inhibition by tumor-conditioned media in the presence or absence of bevacizumab correlates with colorectal cancer patient survival. Monitoring the influence of the tumor ... -
Deoxycholic acid promotes development of gastroesophageal reflux disease and Barrett's oesophagus by modulating integrin-??v trafficking
FINN, STEPHEN; O'SULLIVAN, JACINTHA; LONG, AIDEEN; BYRNE, ANNE-MARIE; REYNOLDS, JOHN (2017) -
Differential expression of mitochondrial energy metabolism profiles across the metaplasia-dysplasia-adenocarcinoma disease sequence in Barrett's oesophagus.
RAVI, NARAYANASAMY; O'SULLIVAN, JACINTHA; REYNOLDS, JOHN; LYNAM-LENNON, NIAMH (2014) -
LC3B globular structures correlate with survival in esophageal adenocarcinoma
O'SULLIVAN, JACINTHA; REYNOLDS, JOHN (2015)Background Esophageal adenocarcinoma has the fastest growing incidence of any solid tumor in the Western world. Prognosis remains poor with overall five-year survival rates under 25 %. Only a limited number of patients ... -
Maternal topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of zebrafish top2a -/- mutants
O'SULLIVAN, JACINTHA (2011)Genetic alterations in human topoisomerase II alpha (TOP2A) are linked to cancer susceptibility. TOP2A decatenates chromosomes and thus is necessary for multiple aspects of cell division including DNA replication, chromosome ... -
Mitochondrial mutagenesis correlates with the local inflammatory environment in arthritis
O'SULLIVAN, JACINTHA (2012)Background: To examine the association between mitochondrial mutagenesis and the proinflammatory microenvironment in patients with inflammatory arthritis. Methods: Fifty patients with inflammatory arthritis underwent ... -
Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer
O'SULLIVAN, JACINTHA (2016)Colorectal cancer (CRC) is a leading cause of cancer deaths. Molecularly targeted therapies (e.g. bevacizumab) have improved survival rates but drug resistance ultimately develops and newer therapies are required. We ... -
Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer.
O'SULLIVAN, JACINTHA (2014)Background Bevacizumab improves progression free survival (PFS) and overall survival (OS) in metastatic colorectal cancer patients however currently there are no biomarkers that predict response to this treatment. The ... -
A prospective investigation of predictive and modifiable risk factors for breast cancer in unaffected BRCA1 and BRCA2 gene carriers
O'SULLIVAN, JACINTHA (2013)Background Breast cancer is the most common female cancer worldwide. The lifetime risk of a woman being diagnosed with breast cancer is approximately 12.5%. For women who carry the deleterious mutation in either of the ... -
The role of energy metabolism in driving disease progression in inflammatory, hypoxic and angiogenic environments
O'SULLIVAN, JACINTHA (2015)Cellular metabolism plays a crucial role in primed inflammatory, hypoxic and an - giogenic microenvironments by supporting disease progression in a range of disease entities. To adapt to fluctuating st ... -
Successful tumour necrosis factor (TNF) blocking therapy suppresses oxidative stress and hypoxiainduced mitochondrial mutagenesis in inflammatory arthritis
O'SULLIVAN, JACINTHA (2011)INTRODUCTION: To examine the effects of tumour necrosis factor (TNF) blocking therapy on the levels of early mitochondrial genome alterations and oxidative stress. METHODS: Eighteen inflammatory arthritis patients ... -
Tumour Tissue Microenvironment Can Inhibit Dendritic Cell Maturation in Colorectal Cancer
O'SULLIVAN, JACINTHA (2011)Inflammatory mediators in the tumour microenvironment promote tumour growth, vascular development and enable evasion of anti-tumour immune responses, by disabling infiltrating dendritic cells. However, the constituents ...